ArticleInternational journal of environmental research and public health2020
Non-Cancer Chronic Pain Conditions and Risk for Incident Alzheimer's Disease and Related Dementias in Community-Dwelling Older Adults: A Population-Based Retrospective Cohort Study of United States Medicare Beneficiaries, 2001-2013.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Chronic Pain and the Risk of Dementia: A Systematic Review and Meta-Analysis.Current pain and headache reports · 2026Pooled it
- Longitudinal associations of pain and cognitive decline in community-dwelling older adults.Psychology and aging · 2022Trial
- Chronic pain as a risk factor for Alzheimer's disease pathology: a longitudinal ADNI study.Alzheimer's research & therapy · 2026Article
- Associations between pain and cognitive impairment in older adults: findings from the birjand longitudinal aging study.Aging clinical and experimental research · 2026Article
- Alzheimer's disease and related dementias in rural medicare populations: a scoping review.BMC geriatrics · 2026Article
- The association between preoperative chronic pain and postoperative delirium in elderly patients undergoing elective orthopedic surgery.Frontiers in medicine · 2026Article
- Subjective memory concerns and cognitive aging in Puerto Rican older adults: the moderating role of chronic pain.Innovation in aging · 2026Article
- Association between cumulative atherogenic index of plasma and dementia risk score in middle-aged and elderly adults: a longitudinal analysis of the CHARLS cohort.European journal of medical research · 2025Article
- Chronic pain and subjective memory problems are dynamic risk factors for functional decline: An ACTIVE longitudinal study.Experimental gerontology · 2025Article
- Causal Relationships Between Neuropathic Pain and Alzheimer's Disease: A Multi-Omics Mendelian Randomization Study with Exploratory Evidence of a Potential Protective Role of Diabetic Neuropathy.Journal of pain research · 2025Article
- Elevated C-Reactive Protein in Older Men With Chronic Pain: Association With Plasma Amyloid Levels and Hippocampal Volume.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Review
- Chronic Non-cancer Pain and Associated Risks of Incident Mild Cognitive Impairment and Alzheimer's Disease and Related Dementias in Middle-Aged and Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Article
- Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men.The journal of pain · 2024Article
- Association between chronic pain and dementia: a systematic review and meta-analysis.European journal of ageing · 2024Review
- Correlates of neurocognitive performance in older adults with chronic pain and negative emotions: baseline data from the problem adaptation therapy for pain (PATH-pain) randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Pain and incident cognitive impairment in very old Mexican American adults.Journal of the American Geriatrics Society · 2024Article
- Association between chronic pain and risk of incident dementia: findings from a prospective cohort.BMC medicine · 2023Article
- Chronic pain is a risk factor for incident Alzheimer's disease: a nationwide propensity-matched cohort using administrative data.Frontiers in aging neuroscience · 2023Article
- Socioeconomic and sex inequalities in chronic pain: A population-based cross-sectional study.PloS one · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Accumulating evidence suggests that certain chronic pain conditions may increase risk for incident Alzheimer's disease and related dementias (ADRD). Rigorous longitudinal research remains relatively sparse, and the relation of overall chronic pain condition burden to ADRD risk remains little studied, as has the potential mediating role of sleep and mood disorders. In this retrospective cohort study, we investigated the association of common non-cancer chronic pain conditions (NCPC) at baseline to subsequent risk for incident ADRD, and assessed the potential mediating effects of mood and sleep disorders, using baseline and 2-year follow-up data using 11 pooled cohorts (2001-2013) drawn from the U.S. Medicare Current Beneficiaries Survey (MCBS). The study sample comprised 16,934 community-dwelling adults aged ≥65 and ADRD-free at baseline. NCPC included: headache, osteoarthritis, joint pain, back or neck pain, and neuropathic pain, ascertained using claims data; incident ADRD (N = 1149) was identified using claims and survey data. NCPC at baseline remained associated with incident ADRD after adjustment for sociodemographics, lifestyle characteristics, medical history, medications, and other factors (adjusted odds ratio (AOR) for any vs. no NCPC = 1.21, 95% confidence interval (CI) = 1.04-1.40;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.