Evidence map›Paper›PMID 32750415›Full record

ArticleCellular signalling2020

Sigma-1 receptor ablation impedes adipocyte-like differentiation of mouse embryonic fibroblasts.

Huan Yang, Hongtao Shen, Jing Li, Kristin I Stanford, Lian-Wang Guo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Sphingoid Bases Regulate the Sigma-1 Receptor-Sphingosine andInternational journal of molecular sciences · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Huan YangDepartment of Surgery, University of Wisconsin, Madison, WI 53705, USA.
Hongtao ShenDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Jing LiDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Kristin I StanfordDepartments of Physiology & Cell Biology, College of Medicine; Davis Heart and Lung Research Institute, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Lian-Wang GuoDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: lg8zr@virginia.edu.
University of Virginia · USThe Ohio State University Wexner Medical Center · USUniversity of Wisconsin–Madison · US

Funding

A Novel Role for Brown Adipose Tissue Enhance Heart Function and MetabolismR01HL138738 · NHLBI · OHIO STATE UNIVERSITY · PI STANFORD, KRISTIN I · 2017 to 2021
$2.3M
Sigma-1 Chaperone-Mediated in vivo Neuroprotection in the RetinaR01EY022678 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, LIANWANG · 2012 to 2016
$1.7M
BET Bromodomain proteins as Novel Epigenetic Targets for prevention of Intimal Hyperplasia after Vascular SurgeryR01HL133665 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, LIANWANG · 2016 to 2019
$1.6M
NEI NIH HHS R01 EY022678NHLBI NIH HHS R01 HL133665NHLBI NIH HHS R01 HL138738
6 · The paper itself

Abstract

The sigma-1 receptor (Sig1R) is a unique ligand-operated endoplasmic reticulum (ER) protein without any mammalian homolog. It has long been a pharmacological target for intervention of psychiatric disorders, and recently garnered refreshed interest for its neuroprotective potential. Though reported to modulate various intracellular events, its influence on cell identity is little known. We explored a role for Sig1R in adipocyte differentiation. We induced adipogenic differentiation of mouse embryonic fibroblasts (MEFs) with a differentiation medium. MEFs were isolated from Sigmar1

Indexed as

AdipocytesAnimalsCell DifferentiationCells, CulturedFemaleFibroblastsMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, sigmaSigma-1 ReceptorReceptors, sigmaSigma-1 ReceptorAdipogenic inductionBody weight gainMouse embryonic fibroblastSigma-1 receptor

Identifiers

PMID32750415
PMCPMC7530065
OpenAlexW3046893513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.