Observational studyCancer medicine2020
Increased curative treatment is associated with decreased prostate cancer-specific and overall mortality in senior adults with high-risk prostate cancer; results from a national registry-based cohort study.
Observational study in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Self-reported health, function, and use of health care services in older prostate cancer survivors compared to matched controls: a cross-sectional study.Journal of cancer survivorship : research and practice · 2026Article
- Potential gains from radical treatment of men with prostate cancer according to life expectancy.BJUI compass · 2025Article
- Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls.European urology open science · 2025Article
- Prostate-derived circulating microRNAs add prognostic value to prostate cancer risk calculators.Journal of extracellular biology · 2023Article
- Cardiovascular outcomes after curative prostate cancer treatment: A population-based cohort study.Frontiers in oncology · 2023Article
- High-dose-rate brachytherapy boost for elderly patients with intermediate to high-risk prostate cancer: 5-year clinical outcome of the PROSTAGE cohort.Clinical and translational radiation oncology · 2022Article
- Irradiation of localized prostate cancer in the elderly: A systematic literature review.Clinical and translational radiation oncology · 2022Review
- The Dilemma of Misclassification Rates in Senior Patients With Prostate Cancer, Who Were Treated With Robot-Assisted Radical Prostatectomy: Implications for Patient Counseling and Diagnostics.Frontiers in surgery · 2022Article
- Observational
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between curative treatment (CurTrt) and mortality in senior adults (≥70 years) with high-risk prostate cancer (PCa) is poorly documented. In a population-based cohort we report temporal trends in treatment and PCa-specific mortality (PCSM), investigating the association between CurTrt and mortality in senior adults with high-risk PCa, compared to findings in younger men (<70 years).
methodsObservational study from the Cancer Registry of Norway. Patients with high-risk PCa were stratified for three diagnostic periods (2005-08, 2009-12 and 2013-16), age (<70, vs ≥70) and primary treatment (CurTrt: Radical prostatectomy (RP), Radiotherapy (RAD) vs no curative treatment (NoCurTrt)). Competing risk and Kaplan-Meier methods estimated PCSM and overall mortality (OM), respectively. Multivariable logistic regression models estimated odds for CurTrt, and multivariable Fine Gray and Cox regression models evaluated the hazard ratios for PCSM and OM.
resultsOf 19 763 evaluable patients, 54% were aged ≥70 years. Senior adults had more unfavorable PCa characteristics than younger men. Across diagnostic periods, use of CurTrt increased from 15% to 51% in men aged ≥70 and 65% to 81% in men aged < 70 years. With median five years follow-up, PCSM decreased in all patients (P < .05), in the third period restricted to senior adults. In all patients NoCurTrt was associated with three-fold higher 5-year PCSM and two-fold higher OM compared to CurTrt.
conclusionsIn high-risk PCa patients, increased use of CurTrt, greatest in senior men, was observed along with decreased PCSM and OM in both senior and younger adults. CurTrt should increasingly be considered in men ≥70 years.
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