ArticleBlood advances2020
Development and validation of a universal blood donor genotyping platform: a multinational prospective study.
Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Red cell specifications for blood group matching in patients with haemoglobinopathies: An updated systematic review and clinical practice guideline from the International Collaboration for Transfusion Medicine Guidelines.British journal of haematology · 2025Pooled it
- Proof-of-principle: nanopore adaptive sampling enables full blood group genome analysis and resolution of hybrid alleles.Blood advances · 2026Article
- AlphaGenome-enabled analysis of non-coding regulatory variants underlyingbioRxiv : the preprint server for biology · 2026Article
- Array genotyping of transfusion-relevant blood cell antigens in 6946 ancestrally diverse study participants.Blood · 2025Article
- Exploring the experiences of hemochromatosis (HHC) patients who undergo therapeutic venesection at a blood collection agency.Transfusion · 2025Article
- Screening of pregnant women for foetal neonatal alloimmune thrombocytopenia: A cost-utility analysis.Vox sanguinis · 2025Article
- A standards-based application for improving platelet transfusion workflow.Journal of pathology informatics · 2025Article
- Genomic characterization of clinically significant blood group variants in Aboriginal Australians.Blood transfusion = Trasfusione del sangue · 2024Article
- SMIM1 absence is associated with reduced energy expenditure and excess weight.Med (New York, N.Y.) · 2024Article
- Equity in blood transfusion precision services.International journal for equity in health · 2024Article
- A machine-learning method for biobank-scale genetic prediction of blood group antigens.PLoS computational biology · 2024Article
- Evaluation of Single Nucleotide Variants in Intron 1 of the ABO Gene as Diagnostic Markers for the ATransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Article
- Long-Read Sequencing in Blood Group Genetics.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Haplotype sequence collection of ABO blood group alleles by long-read sequencing reveals putative A1-diagnostic variants.Blood advances · 2023Article
- Donor and non-donor perspectives on receiving information from routine genomic testing of donor blood.Transfusion · 2023Article
- Blood donor biobank and HLA imputation as a resource for HLA homozygous cells for therapeutic and research use.Stem cell research & therapy · 2022Article
- High-throughput method for the hybridisation-based targeted enrichment of long genomic fragments for PacBio third-generation sequencing.NAR genomics and bioinformatics · 2022Article
- Using whole-genome sequencing to characterize clinically significant blood groups among healthy older Australians.Blood advances · 2022Article
- How to avoid the problem of erythrocyte alloimmunization in sickle cell disease.Hematology. American Society of Hematology. Education Program · 2021Review
- Current advances in transfusion medicine 2020: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee.Transfusion · 2021Review
Corrections and comments
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Authors and funding
41 authors at 9 institutions in 5 countries.
Funding
Abstract
Each year, blood transfusions save millions of lives. However, under current blood-matching practices, sensitization to non-self-antigens is an unavoidable adverse side effect of transfusion. We describe a universal donor typing platform that could be adopted by blood services worldwide to facilitate a universal extended blood-matching policy and reduce sensitization rates. This DNA-based test is capable of simultaneously typing most clinically relevant red blood cell (RBC), human platelet (HPA), and human leukocyte (HLA) antigens. Validation was performed, using samples from 7927 European, 27 South Asian, 21 East Asian, and 9 African blood donors enrolled in 2 national biobanks. We illustrated the usefulness of the platform by analyzing antibody data from patients sensitized with multiple RBC alloantibodies. Genotyping results demonstrated concordance of 99.91%, 99.97%, and 99.03% with RBC, HPA, and HLA clinically validated typing results in 89 371, 3016, and 9289 comparisons, respectively. Genotyping increased the total number of antigen typing results available from 110 980 to >1 200 000. Dense donor typing allowed identification of 2 to 6 times more compatible donors to serve 3146 patients with multiple RBC alloantibodies, providing at least 1 match for 176 individuals for whom previously no blood could be found among the same donors. This genotyping technology is already being used to type thousands of donors taking part in national genotyping studies. Extraction of dense antigen-typing data from these cohorts provides blood supply organizations with the opportunity to implement a policy of genomics-based precision matching of blood.
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