Evidence map›Paper›PMID 32749732›Full record

ArticleChembiochem : a European journal of chemical biology2020

Design of a Multiuse Photoreactor To Enable Visible-Light Photocatalytic Chemical Transformations and Labeling in Live Cells.

Noah B Bissonnette, Keun Ah Ryu, Tamara Reyes-Robles, Sharon Wilhelm, Jake H Tomlinson, Kelly A Crotty, Erik C Hett, Lee R Roberts, Daria J Hazuda, M Jared Willis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Advancement in Organic Synthesis through High Throughput Experimentation.Chemistry methods : new approaches to solving problems in chemistry · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Noah B BissonnetteExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Keun Ah RyuExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Tamara Reyes-RoblesExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Sharon WilhelmExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Jake H TomlinsonExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Kelly A CrottyExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Erik C HettExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Lee R RobertsExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
Daria J HazudaExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.
M Jared WillisEfficieny Aggregators, 1207 FM 359, Richmond, TX 77406, USA.
Rob C OslundExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.ORCID 0000-0002-2920-9532
Olugbeminiyi O FadeyiExploratory Science Center, Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the growing use of visible-light photochemistry in both chemistry and biology, no general low-heat photoreactor for use across these different disciplines exists. Herein, we describe the design and use of a standardized photoreactor for visible-light-driven activation and photocatalytic chemical transformations. Using this single benchtop photoreactor, we performed photoredox reactions across multiple visible light wavelengths, a high-throughput photocatalytic cross-coupling reaction, and in vitro labeling of proteins and live cells. Given the success of this reactor in all tested applications, we envision that this multi-use photoreactor will be widely used in biology, chemical biology, and medicinal chemistry settings.

Indexed as

LightPhotobioreactorsBiotinCatalysisCell Line, TumorEquipment DesignHumansMolecular StructurePhotochemical ProcessesTyramineBiotinTyraminelive-cell labelingmultiplex capabilitiesphotochemistryphotoreactorsphotoredoxproteins

Identifiers

PMID32749732
PMCPMC7756335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.