SynthesisIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2020
Gastrointestinal and hepatic manifestations of Corona Virus Disease-19 and their relationship to severe clinical course: A systematic review and meta-analysis.
Synthesis in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04854941 (Efficacy of Probiotics), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Probiotics (Lactobacillus Rhamnosus, Bifidobacterium Bifidum, Bifidobacterium Longum Subsp. Infantis and Bifidobacterium Longum) in the Treatment of Hospitalised Patients With Novel Coronavirus Infection
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Prevalence and outcomes of malnutrition among hospitalized COVID-19 patients: A systematic review and meta-analysis.Clinical nutrition ESPEN · 2021Pooled it
- COVID-19 gastrointestinal manifestations: a systematic review.Revista da Sociedade Brasileira de Medicina Tropical · 2020Pooled it
- Observational
- Lung Abscess in a COVID-19 Patient: A Case Report.Advanced biomedical research · 2026Article
- Clinical Characteristics and Treatment Outcomes of COVID-19 Patients at Eka Kotebe General Hospital, Addis Ababa, Ethiopia.The American journal of tropical medicine and hygiene · 2022Article
- Global research production pertaining to gastrointestinal involvement in COVID-19: A bibliometric and visualised study.World journal of gastrointestinal surgery · 2022Article
- Postinfection Irritable Bowel Syndrome.Gut and liver · 2022Review
- Post-infection functional gastrointestinal disorders following coronavirus disease-19: A case-control study.Journal of gastroenterology and hepatology · 2022Article
- Article
- Clinical presentation of COVID-19 in patients with inflammatory bowel disease: a systematic review and meta-analysis.Intestinal research · 2022Article
- Digestive System Involvement During Coronavirus Disease 2019; the Newest Clinical Features and Potential Mechanisms : Digestive System Involvements and COVID-19.Galen medical journal · 2022Review
- Is Gut Involvement a Cause or Effect of COVID-19?The Malaysian journal of medical sciences : MJMS · 2021Article
- Frequency and Impact of Preadmission Digestive Symptoms on Outcome in Severe COVID-19: A Prospective Observational Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Transmission of severe acute respiratory syndrome coronavirus 2World journal of clinical cases · 2021Review
- Elevated liver enzymes portends a higher rate of complication and death in SARS-CoV-2.World journal of hepatology · 2021Article
- The oxygen dissociation curve of blood in COVID-19.American journal of physiology. Lung cellular and molecular physiology · 2021Review
- Global burden of acute myocardial injury associated with COVID-19: A systematic review, meta-analysis, and meta-regression.Annals of medicine and surgery (2012) · 2021Review
- COVID-19-related thyroid conditions (Review).Experimental and therapeutic medicine · 2021Review
- Article
- Serological surveillance of SARS-CoV-2: Six-month trends and antibody response in a cohort of public health workers.The Journal of infection · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany case series on Corona Virus Disease (COVID-19) have reported gastrointestinal (GI) and hepatic manifestations in a proportion of cases; however, the data is conflicting. The relationship of GI and hepatic involvement with severe clinical course of COVID-19 has also not been explored.
objectivesThe main objectives were to determine the frequency of GI and hepatic manifestations of COVID-19 and to explore their relationship with severe clinical course.
methodsWe searched PubMed for studies published between January 1, 2020, and March 25, 2020, with data on GI and hepatic manifestations in adult patients with COVID-19. These data were compared between patients with severe and good clinical course using the random-effects model and odds ratio (OR) as the effect size. If the heterogeneity among studies was high, sensitivity analysis was performed for each outcome.
resultsWe included 62 studies (8301 patients) in the systematic review and 26 studies (4676 patients) in the meta-analysis. Diarrhea was the most common GI symptom (9%), followed by nausea/vomiting (5%) and abdominal pain (4%). Transaminases were abnormal in approximately 25%, bilirubin in 9%, prothrombin time (PT) in 7%, and low albumin in 60%. Up to 20% patients developed severe clinical course, and GI and hepatic factors associated with severe clinical course were as follows: diarrhea (OR 2), high aspartate aminotransferase (OR 1.4), high alanine aminotransferase (OR 1.6), high bilirubin (OR 2.4), low albumin (OR 3.4), and high PT (OR 3).
conclusionsGI and hepatic involvement should be sought in patients with COVID-19 since it portends severe clinical course. The pathogenesis of GI and hepatic involvement needs to be explored in future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.