ArticleEuropean radiology2021
Magnetic resonance parametric mapping of the spleen for non-invasive assessment of portal hypertension.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 29 citations in OpenAlex.
- Native Spleen T1 Mapping for the Assessment of Hepatic Congestion in Children With Congenital Heart Disease.Circulation reports · 2026Article
- An empirical explanation of why T2 of tissue and T2 related to field inhomogeneity contribute to the liver apparent diffusion coefficient (ADC) measure in opposite directions.Quantitative imaging in medicine and surgery · 2026Article
- Long-term cardiac remodeling after transjugular intrahepatic portosystemic shunt placement: a cardiac MRI study.European radiology · 2026Article
- Advances in Precise Assessment of Portal Pressure in Porto-sinusoidal Vascular Disease.Journal of clinical and translational hepatology · 2026Review
- Four-dimensional flow MRI for identifying high-risk esophageal varices: a comparison and combination with spleen volume and splenic extracellular volume fraction.Insights into imaging · 2026Article
- Clinical validation of T1ρ mapping for the assessment of hepatic fibrosis in patients with chronic liver disease.European radiology · 2026Article
- [Novel advances following the integration of Baveno VII consensus definitions for the non-invasive testing of portal hypertension].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- CT-based hepatic and splenic extracellular volume fraction and iodine washout rate for noninvasive assessment of portal hypertension: a preliminary study.BMC medical imaging · 2026Article
- Separation of liver focal nodular hyperplasia (FNH) and liver malignant tumors by a combination of T2-weighted imaging signal and three diffusion magnetic resonance metrics of diffusion-derived vessel density, slow diffusion coefficient, and apparent diffusion coefficient.Journal of gastrointestinal oncology · 2026Article
- Reliable diagnosis of liver focal nodular hyperplasia by a combination of T2 weighted signal and three diffusion magnetic resonance metrics of diffusion-derived 'vessel density', slow diffusion coefficient, and apparent diffusion coefficient: a validation study of two centers' data.Quantitative imaging in medicine and surgery · 2026Article
- An explanation for why tissues with T2 of around 70 milliseconds always measure low MRI apparent diffusion coefficient (ADC).Quantitative imaging in medicine and surgery · 2025Article
- Letter to the Editor: Harmonization of quantitative liver function evaluation using gadoxetate disodium-enhanced magnetic resonance imaging.European radiology · 2025Article
- Detection and severity stratification of chronic liver disease using magnetic resonance intravoxel incoherent motion and elastography.Radiology advances · 2025Article
- Assessment of high-risk gastroesophageal varices in cirrhotic patients using quantitative parameters from dual-source dual-energy CT.Abdominal radiology (New York) · 2025Article
- T1 Mapping of the Abdomen, From theAJR. American journal of roentgenology · 2025Review
- Vasomics of the liver.Gut · 2025Review
- Liver segmental volumes and their relationship with 5-year prognostication.Abdominal radiology (New York) · 2025Article
- A signal model for fat-suppressed TNMR in biomedicine · 2025Article
- Magnetic resonance imaging T1 mapping of the liver, pancreas and spleen in children.Abdominal radiology (New York) · 2024Article
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Authors and funding
15 authors at 2 institutions in 1 country.
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Abstract
objectivesIn patients with advanced liver disease, portal hypertension is an important risk factor, leading to complications such as esophageal variceal bleeding, ascites, and hepatic encephalopathy. This study aimed to determine the diagnostic value of T1 and T2 mapping and extracellular volume fraction (ECV) for the non-invasive assessment of portal hypertension.
methodsIn this prospective study, 50 participants (33 patients with indication for trans-jugular intrahepatic portosystemic shunt (TIPS) and 17 healthy volunteers) underwent MRI. The derivation and validation cohorts included 40 and 10 participants, respectively. T1 and T2 relaxation times and ECV of the liver and the spleen were assessed using quantitative mapping techniques. Direct hepatic venous pressure gradient (HVPG) and portal pressure measurements were performed during TIPS procedure. ROC analysis was performed to compare diagnostic performance.
resultsSplenic ECV correlated with portal pressure (r = 0.72; p < 0.001) and direct HVPG (r = 0.50; p = 0.003). No significant correlations were found between native splenic T1 and T2 relaxation times with portal pressure measurements (p > 0.05, respectively). In the derivation cohort, splenic ECV revealed a perfect diagnostic performance with an AUC of 1.000 for the identification of clinically significant portal hypertension (direct HVPG ≥ 10 mmHg) and outperformed other parameters: hepatic T2 (AUC, 0.731), splenic T2 (AUC, 0.736), and splenic native T1 (AUC, 0.806) (p < 0.05, respectively). The diagnostic performance of mapping parameters was comparable in the validation cohort.
conclusionSplenic ECV was associated with portal pressure measurements in patients with advanced liver disease. Future studies should explore the diagnostic value of parametric mapping accross a broader range of pressure values. KEY POINTS: • Non-invasive assessment and monitoring of portal hypertension is an area of unmet interest. • Splenic extracellular volume fraction is strongly associated with portal pressure in patients with end-stage liver disease. • Quantitative splenic and hepatic MRI-derived parameters have a potential to become a new non-invasive diagnostic parameter to assess and monitor portal pressure.
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