Evidence map›Paper›PMID 32749514›Full record

ArticleArchives of toxicology2020

Neurite outgrowth inhibitory levels of organophosphates induce tissue transglutaminase activity in differentiating N2a cells: evidence for covalent adduct formation.

Ibtesam S Almami, Maha A Aldubayan, Shatha G Felemban, Najiah Alyamani, Richard Howden, Alexander J Robinson, Tom D Z Pearson, David Boocock, Alanood S Algarni, A Christopher Garner and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Ibtesam S AlmamiSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Maha A AldubayanSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Shatha G FelembanSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Najiah AlyamaniSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Richard HowdenSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Alexander J RobinsonSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Tom D Z PearsonSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
David BoocockSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Alanood S AlgarniSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
A Christopher GarnerSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Martin GriffinDepartment of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK.
Philip L R BonnerSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Alan J HargreavesSchool of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK. alan.hargreaves@ntu.ac.uk.ORCID http://orcid.org/0000-0001-9754-5477
Nottingham Trent University · GBQassim University · SAAston University · GBBirmingham City University · GBSoliman Fakeeh Hospital · SAUmm al-Qura University · SAUniversity of Jeddah · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organophosphate compounds (OPs) induce both acute and delayed neurotoxic effects, the latter of which is believed to involve their interaction with proteins other than acetylcholinesterase. However, few OP-binding proteins have been identified that may have a direct role in OP-induced delayed neurotoxicity. Given their ability to disrupt Ca

Indexed as

AminesAnimalsBiotinCell DifferentiationCell Line, TumorCell SurvivalChlorpyrifosGTP-Binding ProteinsHumansMiceNeuroblastomaNeuronal OutgrowthOrganophosphatesOrganophosphorus CompoundsProtein Glutamine gamma Glutamyltransferase 2Proteomics5-(biotinamido)pentylamineAminesBiotinChlorpyrifosGTP-Binding ProteinsO,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphateOrganophosphatesOrganophosphorus Compoundsphenylsaligenin cyclic phosphateProtein Glutamine gamma Glutamyltransferase 2Reactive Oxygen SpeciesTgm2 protein, ratTransglutaminasesCovalent adductNeurite outgrowthOrganophosphate toxicityTissue transglutaminase

Identifiers

PMID32749514
PMCPMC7603472
OpenAlexW3047212402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.