Evidence map›Paper›PMID 32749118›Full record

ReviewCritical reviews in biomedical engineering2020

Nanopore Fabrication and Application as Biosensors in Neurodegenerative Diseases.

Brian Lenhart, Xiaojun Wei, Zehui Zhang, Xiaoqin Wang, Qian Wang, Chang Liu

Abstract readReview
In one paragraph

Review in Critical reviews in biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Sensors and actuators. B, Chemical · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian LenhartDepartment of Chemical Engineering, University of South Carolina, Columbia, SC.
Xiaojun WeiDepartment of Chemical Engineering, University of South Carolina, Columbia, SC; Biomedical Engineering Program, University of South Carolina, Columbia, SC.
Zehui ZhangBiomedical Engineering Program, University of South Carolina, Columbia, SC.
Xiaoqin WangDepartment of Chemical Engineering, University of South Carolina, Columbia, SC.
Qian WangDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC.
Chang LiuDepartment of Chemical Engineering, University of South Carolina, Columbia, SC; Biomedical Engineering Program, University of South Carolina, Columbia, SC.

Funding

A Solid-State Nanopore Biosensor for Rapid Detection of Mycobacterium tuberculosis Antigens in Pediatric Blood SamplesK22AI136686 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LIU, CHANG · 2019 to 2020
$265k
NIAID NIH HHS K22 AI136686
6 · The paper itself

Abstract

Since its conception as an applied biomedical technology nearly 30 years ago, nanopore is emerging as a promising, high-throughput, biomarker-targeted diagnostic tool for clinicians. The attraction of a nanopore-based detection system is its simple, inexpensive, robust, user-friendly, high-throughput blueprint with minimal sample preparation needed prior to analysis. The goal of clinical-based nanopore biosensing is to go from sample acquisition to a meaningful readout quickly. The most extensive work in nanopore applications has been targeted at DNA, RNA, and peptide identification. Although, biosensing of pathological biomarkers, which is covered in this review, is on the rise. This review is broken into two major sections: (i) the current state of existing biological, solid state, and hybrid nanopore systems and (ii) the applications of nanopore biosensors toward detecting neurodegenerative biomarkers.

Indexed as

Biosensing TechniquesNanoporesAmyloidBacterial Outer Membrane ProteinsBacterial ProteinsBiotechnologyDNAEquipment DesignEscherichia coli ProteinsHemolysin ProteinsHumansNanotechnologyNeurodegenerative DiseasesPositron-Emission TomographyProtein ConformationRNAAmyloidBacterial Outer Membrane ProteinsBacterial ProteinsDNAEscherichia coli ProteinsFhuA protein, E coliHemolysin ProteinsRNAWater

Identifiers

PMID32749118
PMCPMC8020784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.