Evidence map›Paper›PMID 32748963›Full record

ArticleTransfusion2020

Rapid establishment of a COVID-19 convalescent plasma program in a regional health care delivery network.

Douglas Blackall, Shephali Wulff, Timothy Roettger, Lauren Jacobs, Alexandre Lacasse, Manokiran Patri, Phillip Zinser, Francisco Pherez, Zafar Jamkhana, Sharon E Frey and 3 more

Abstract read
In one paragraph

Article in Transfusion, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Douglas BlackallDepartment of Pathology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0003-1031-8816
Shephali WulffSSM Health Saint Joseph Hospital, Saint Charles, Missouri, USA.
Timothy RoettgerSSM-STL Pharmacy, Saint Louis, Missouri, USA.
Lauren JacobsSSM-STL Pharmacy, Saint Louis, Missouri, USA.
Alexandre LacasseSSM Health Saint Mary's Hospital, Saint Louis, Missouri, USA.
Manokiran PatriSSM Health DePaul Hospital, Bridgeton, Missouri, USA.
Phillip ZinserSSM Health DePaul Hospital, Bridgeton, Missouri, USA.
Francisco PherezSSM Health Saint Clare Hospital, Fenton, Missouri, USA.
Zafar JamkhanaDepartment of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Sharon E FreyDepartment of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Linda SmithSSM-STL Laboratory, Saint Louis, Missouri, USA.
Ruchika GoelMississippi Valley Regional Blood Center, Springfield, Illinois, USA.ORCID 0000-0001-9653-9905
Louis KatzMississippi Valley Regional Blood Center, Springfield, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19 convalescent plasma (CCP) represents an appealing approach to the treatment of patients with infections due to SARS-CoV-2. We endeavored to quickly establish a sustainable CCP transfusion program for a regional network of health care facilities. STUDY DESIGN AND

methodsA regional collaborative group was activated to address the issues necessary to implementing a CCP transfusion program and making the program sustainable. A wide range of health care providers including physicians (critical care, infectious disease, transfusion medicine), nurses, pharmacists, laboratorians, and information technology (IT) specialists were required to make the program a success.

resultsThe CCP implementation team initially consisted of four members but quickly grew to a group of nearly 20 participants based on different issues related to program implementation. Overall, six major implementation "themes" were addressed: (a) registration of individual hospitals and principal investigators with a national investigational new drug research protocol; (b) collaboration with a regional blood donor center; (c) targeted recruitment of convalesced donors; (d) IT issues related to all aspects of CCP ordering, distribution, and transfusion; (e) prioritization of patients to receive CCP; and (f) evaluation of CCP products including antibody characteristics and patient response to therapy.

conclusionWithin 4 weeks of initiation, CCP was successfully transfused at multiple hospitals in our regional health care delivery system. A program infrastructure was established that will make this program sustainable into the future. This approach has broader implications for the success of multi-institutional programs requiring rapid implementation.

Indexed as

AdultAgedBlood DonorsBlood TransfusionConvalescenceCOVID-19COVID-19 SerotherapyCritical CareDelivery of Health CareFemaleHospitalsHumansImmunization, PassiveMaleMiddle AgedSARS-CoV-2

Identifiers

PMID32748963
PMCPMC7436587

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.