ArticleJournal of clinical medicine2020
The Subgingival Microbiome in Patients with Down Syndrome and Periodontitis.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Surveying immune and inflammatory alterations in periodontitis among individuals with Down syndrome: A preliminary cross-sectional study.Journal of periodontology · 2026Article
- Interleukin-1 Polymorphisms in Caucasian Adults with Down Syndrome and Advanced Periodontitis: A Cross-Sectional Study.Dentistry journal · 2026Article
- Periodontal Microbial Profiles Across Periodontal Conditions in Pediatric Subjects: A Narrative Review.Microorganisms · 2025Review
- Periodontal Status and Herpesiviridae, Bacteria, and Fungi in Gingivitis and Periodontitis of Systemically Compromised Pediatric Subjects: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Salivary Lactoferrin Levels and Polymorphisms in Down Syndrome Individuals with Periodontitis.Journal of clinical medicine · 2025Article
- Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape.Frontiers in oral health · 2025Article
- Human oral microbiome and its influence on mental health and brain disorders.AIMS microbiology · 2025Review
- Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy.Antibiotics (Basel, Switzerland) · 2022Article
- Characterization of the unique oral microbiome of children with Down syndrome.Scientific reports · 2022Article
- Molecular Detection ofMicroorganisms · 2022Article
- Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa.Physiological reports · 2022Article
- Multi-omics analysis reveals the host-microbe interactions in aged rhesus macaques.Frontiers in microbiology · 2022Article
- Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study.International journal of molecular sciences · 2021Article
- In Vitro Anti-Biofilm and Antibacterial Properties ofMicroorganisms · 2021Article
- Identification of Neuropeptides as Potential Crosstalks Linking Down Syndrome and Periodontitis Revealed by Transcriptomic Analyses.Disease markers · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo describe the subgingival microbiome of individuals with Down syndrome (DS).
methodsWe conducted a cross-sectional observational study that obtained bacterial DNA samples from 50 patients with DS, 25 with periodontitis (PDS) and 25 with a healthy periodontal condition (HDS). The samples were analyzed by sequencing the 16S rRNA gene V3-V4 hypervariable region using the MiSeq System. Taxonomic affiliations were assigned using the naïve Bayesian classifier integrated in QIIME2 plugins. We evaluated the difference in bacteria abundance between the sample groups using Wilcoxon and Kruskal-Wallis tests. We evaluated the alpha diversity of the identified species using the Observed, Chao1metric, ACE and Shannon indices and evaluated beta diversity with principal coordinate analysis (registration code: 2018/510).
resultsTwenty-one genera and 39 bacterial species showed a significantly different abundance between the study groups. Among the genera,
conclusionWell-recognized periodontal pathogens and newly proposed pathogenic taxa were associated with periodontitis in patients with DS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.