Evidence map›Paper›PMID 32748840›Full record

ArticleJournal of clinical medicine2020

Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy.

Kirk Jensen, Shilpa Thakur, Aneeta Patel, Maria Cecilia Mendonca-Torres, John Costello, Cristiane Jeyce Gomes-Lima, Mary Walter, Leonard Wartofsky, Kenneth Dale Burman, Athanasios Bikas and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Detection of theJournal of clinical medicine · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Opportunities and Challenges of Liquid Biopsy in Thyroid Cancer.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Kirk JensenDepartment of Pediatrics, Endocrine Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Shilpa ThakurNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Aneeta PatelDepartment of Pediatrics, Endocrine Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Maria Cecilia Mendonca-TorresDepartment of Pediatrics, Endocrine Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
John CostelloDepartment of Pediatrics, Endocrine Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Cristiane Jeyce Gomes-LimaNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Mary WalterNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Leonard WartofskyMedStar Health Research Institute, MedStar Washington Hospital Center, Washington, DC 20010, USA.
Kenneth Dale BurmanMedStar Health Research Institute, MedStar Washington Hospital Center, Washington, DC 20010, USA.
Athanasios BikasMedStar Health Research Institute, MedStar Washington Hospital Center, Washington, DC 20010, USA.
Dorina YlliDepartment of Pediatrics, Endocrine Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Vasyl V VaskoDepartment of Pediatrics, Endocrine Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Joanna Klubo-GwiezdzinskaNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Uniformed Services University of the Health Sciences · USMedStar Washington Hospital Center · USNational Institutes of Health · USUniversity of Medicine Tirana · AL

Funding

Application of molecular diagnostics in thyroid cancerZIADK075139 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2017 to 2025
$4.4M
Studies of Benign and Malignant Thyroid DiseaseZIEDK047053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2013 to 2020
$1.9M
Murtha Cancer Center PED-86-90-46NIDDK NIH HHS ZIE DK 04705313
6 · The paper itself

Abstract

The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising tool for the assessment of patients with cancer. We determined the presence of cell-free DNA containing the

Indexed as

BRAFV600ECOLD-PCRdigital PCRliquid biopsypapillary thyroid cancer

Identifiers

PMID32748840
PMCPMC7464493
OpenAlexW3046792547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.