Evidence map›Paper›PMID 32748543›Full record

ArticleChemMedChem2020

Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells.

Wenmin Chen, Shuai Hu, Shuai Mao, Yibin Xu, Hui Guo, Haoxi Li, Michelle T Paulsen, Xinde Chen, Mats Ljungman, Nouri Neamati

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wenmin ChenDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Shuai HuDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Shuai MaoDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Yibin XuDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Hui GuoDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Haoxi LiDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Michelle T PaulsenDepartment of Radiation Oncology, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Xinde ChenDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Mats LjungmanDepartment of Radiation Oncology, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.
Nouri NeamatiDepartments of Medicinal Chemistry, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3291-7131
University of Michigan · US

Funding

ROS-targeted therapy for pancreatic cancer - Diversity SupplementR01CA188252 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEAMATI, NOURI · 2015 to 2020
$2.6M
NCI NIH HHS R01 CA188252
6 · The paper itself

Abstract

Mitochondrial dysfunction is a hallmark of cancer cells and targeting cancer mitochondria has emerged as a promising anti-cancer therapy. Previously, we repurposed chlorambucil by conjugating it to a mitochondrial targeting triphenylphosphonium (TPP) group to design Mito-Chlor, a novel agent that acts on mitochondria DNA (mtDNA). Herein, we show that Mito-Chlor, but not chlorambucil, inhibits the nascent transcription of mtDNA. Clustering analysis of transcriptomic profile of our Bru-seq database led to the identification of another mitochondrial transcription inhibitor SQD1, which inhibits the proliferation of MIA PaCa-2 cells with an IC

Indexed as

Drug DiscoveryAntineoplastic AgentsCell ProliferationDNA, MitochondrialDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMembrane Potential, MitochondrialMolecular StructurePancreatic NeoplasmsStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsDNA, Mitochondrialantitumorbru-seqmitochondrial transcriptionreactive oxygen species (ROS)RNA

Identifiers

PMID32748543
PMCPMC7719573
OpenAlexW3047529586

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.