Evidence map›Paper›PMID 32748316›Full record

ArticleBrain imaging and behavior2021

Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.

Wenjun Su, Tianyuan Zhu, Lihua Xu, Yanyan Wei, Botao Zeng, Tianhong Zhang, Huiru Cui, Junjie Wang, Yuping Jia, Jinhong Wang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Locus-Specific Genetic Associations at theAdvanced genetics (Hoboken, N.J.) · 2026
    Article
  2. International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Genetic polymorphism and neuroanatomical changes in schizophrenia.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Wenjun Su *Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Tianyuan Zhu *Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Lihua XuShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Yanyan WeiShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Botao ZengDepartment of Psychiatry, Qingdao Mental Health Center, Qingdao, 266034, China.
Tianhong ZhangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Huiru CuiShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Junjie WangInstitute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, 215137, Jiangsu, China.
Yuping JiaShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Jinhong WangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Donald C GoffDepartment of Psychiatry, New York University Langone Medical Center, New York, NY, 10016, USA.
Yingying TangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. yytang0522@gmail.com.
Jijun WangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. jijunwang27@163.com.ORCID http://orcid.org/0000-0001-5427-7425
Shanghai Jiao Tong University · CNNYU Langone Health · USQingdao Mental Health Center · CN

Funding

Citalopram in First Episode SchizophreniaR01MH084900 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GOFF, DONALD C. · 2009 to 2013
$2.9M
Clinical Research Center at Shanghai Jiao Tong University School of Medicine DLY201817Clinical Research Center at Shanghai Mental Health Center grants CRC2018ZD01, CRC2018ZD04, and CRC2018YB01Ministry of Science and Technology of China, National Key R&D Program of China 2016YFC1306800National Nature Science Foundation of China grants 81671332, 81971251, 81671329, and 81871050Shanghai Municipal Science and Technology Major Project 2018SHZDZX01Shanghai Science and Technology Committee Foundations 16ZR1430500, 19411969100, 19410710800
6 · The paper itself

Abstract

D-amino acid oxidase activator (DAOA) gene, which plays a crucial role in the process of glutamatergic transmission and mitochondrial function, is frequently linked with the liability for schizophrenia. We aimed to investigate whether the variation of DAOA rs2391191 is associated with alterations in white matter integrity of first-episode schizophrenia (FES) patients; and whether it influences the association between white matter integrity, cognitive function and clinical symptoms of schizophrenia. Forty-six patients with FES and forty-nine healthy controls underwent DTI and were genotyped for DAOA rs2391191. Psychopathological assessments were performed by Brief Psychiatric Rating Scale (BPRS) and Scale for Assessment of Negative Symptoms (SANS). Cognitive function was assessed by MATRICS Consensus Cognitive Battery (MCCB). Schizophrenia patients presented lower fractional anisotropy (FA) and higher radial diffusivity (RD), mainly spreading over the corpus callosum and corona radiata compared with healthy controls. Compared with patients carrying G allele, patients with AA showed lower FA in the body of corpus callosum, and higher RD in the genu of corpus callosum, right superior and anterior corona radiata, and left posterior corona radiata. In patients carrying G allele, FA in body of corpus callosum was positively correlated with working memory, RD in genu of corpus callosum was negatively associated with the speed of processing, working memory, and the composite score of MCCB, while no significant correlations were found in AA homozygotes. In our study, patients with FES presented abnormal white matter integrity in corpus callosum and corona radiata. Furthermore, this abnormality was associated with the genetic variation of DAOA rs2391191, with AA homozygotes showing less white matter integrity in the corpus callosum. Our findings possibly provide further support to the evidence that DAOA regulates the process of glutamatergic neurotransmission and mitochondrial function in the pathophysiological mechanism of schizophrenia.

Indexed as

SchizophreniaWhite MatterAnisotropyCorpus CallosumDiffusion Tensor ImagingGenetic VariationHumansIntracellular Signaling Peptides and ProteinsMagnetic Resonance ImagingDAOA protein, humanIntracellular Signaling Peptides and ProteinsD-amino acid oxidase activator (DAOA)Diffusion tensor imagingFirst-episode schizophrenia

Identifiers

PMID32748316
OpenAlexW3047344218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.