ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021
Bone density and strength from thoracic and lumbar CT scans both predict incident vertebral fractures independently of fracture location.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- What can we learn about bone density in COPD patients from a chest CT? A systematic review.Croatian medical journal · 2024Pooled it
- CT image-based biomarkers for opportunistic screening of osteoporotic fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Single-component imaging and ultrasound-based tools for the assessment of fracture risk.Nature reviews. Rheumatology · 2026Review
- QCT-based geometric, densitometric, and biomechanical properties of the aging human thoracolumbar spine.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Vertebral-level discrimination of incidental vertebral fractures using volumetric BMD, texture features, and finite element-derived fracture load: an exploratory study.Skeletal radiology · 2026Article
- Psoas muscle mass measurement in assessment of imminent fracture risk after vertebral fracture: a single-center case-control study.BMC musculoskeletal disorders · 2026Article
- The Association Between Short-Term Bone Loss and Future Osteoporotic Vertebral Fractures.Clinical interventions in aging · 2026Article
- Deep Learning-Assisted Radiomics for Predicting Thoracolumbar Osteoporotic Vertebral Fractures.Clinical interventions in aging · 2026Article
- Advances in biomechanical modeling of lumbar spine diseases and tumors: gaps, opportunities, and AI integration.Frontiers in bioengineering and biotechnology · 2026Review
- Conventional chest computed tomography-based radiomics for predicting the risk of thoracolumbar osteoporotic vertebral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Article
- Trabecular texture and paraspinal muscle characteristics for prediction of first vertebral fracture: a QCT analysis from the AGES cohort.Frontiers in endocrinology · 2025Article
- Comparison of thoracic vertebrae and L1 CT attenuation in predicting osteoporosis using opportunistic chest CT.Therapeutic advances in musculoskeletal disease · 2025Article
- Thoracic vertebral bone mineral density measured by quantitative computed tomography is associated with fracture risk in lung cancer screening populations: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Using QCT for the prediction of spontaneous age- and gender-specific thoracolumbar vertebral fractures and accompanying distant vertebral fractures.BMC musculoskeletal disorders · 2024Article
- Automated Opportunistic Osteoporosis Screening Using Low-Dose Chest CT among Individuals Undergoing Lung Cancer Screening in a Korean Population.Diagnostics (Basel, Switzerland) · 2024Article
- Comparisons of Hounsfield units and volumetric bone density in discriminating vertebral fractures on lumbar CT scans.The British journal of radiology · 2024Article
- Bone mineral density in lower thoracic vertebra for osteoporosis diagnosis in older adults during CT lung cancer screening.BMC geriatrics · 2024Article
- Assessing Thoracic Vertebral Bone Mineral Density (T8-T10) for Osteoporosis Diagnosis During CT Lung Cancer Screening in Older Adults.International journal of general medicine · 2024Article
- Artificial Intelligence Applications for Osteoporosis Classification Using Computed Tomography.Bioengineering (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
In a population-based study, we found that computed tomography (CT)-based bone density and strength measures from the thoracic spine predicted new vertebral fracture as well as measures from the lumbar spine, suggesting that CT scans at either the thorax or abdominal regions are useful to assess vertebral fracture risk.
introductionPrior studies have shown that computed tomography (CT)-based lumbar bone density and strength measurements predict incident vertebral fracture. This study investigated whether CT-based bone density and strength measurements from the thoracic spine predict incident vertebral fracture and compared the performance of thoracic and lumbar bone measurements to predict incident vertebral fracture.
methodsThis case-control study of community-based men and women (age 74.6 ± 6.6) included 135 cases with incident vertebral fracture at any level and 266 age- and sex-matched controls. We used baseline CT scans to measure integral and trabecular volumetric bone mineral density (vBMD) and vertebral strength (via finite element analysis, FEA) at the T8 and L2 levels. Association between these measurements and vertebral fracture was determined by using conditional logistic regression. Sensitivity and specificity for predicting incident vertebral fracture were determined for lumbar spine and thoracic bone measurements.
resultsBone measurements from T8 and L2 predicted incident vertebral fracture equally well, regardless of fracture location. Specifically, for predicting vertebral fracture at any level, the odds ratio (per 1-SD decrease) for the vBMD and strength measurements at L2 and T8 ranged from 2.0 to 2.7 (p < 0.0001) and 1.8 to 2.8 (p < 0.0001), respectively. Results were similar when predicting fracture only in the thoracic versus the thoracolumbar spine. Lumbar and thoracic spine bone measurements had similar sensitivity and specificity for predicting incident vertebral fracture.
conclusionThese findings indicated that like those from the lumbar spine, CT-based bone density and strength measurements from the thoracic spine may be useful for identifying individuals at high risk for vertebral fracture.
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