ArticleChild psychiatry and human development2021
Treatment Refractory Internalizing Behaviour Across Disorders: An Aetiological Model for Severe Emotion Dysregulation in Adolescence.
Article in Child psychiatry and human development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Drop-out and ineffective treatment in youth with severe and enduring mental health problems: a systematic review.European child & adolescent psychiatry · 2024Pooled it
- Social Anxiety Profiles and Psychopathological Symptom Differences in Spanish Adolescents.Child psychiatry and human development · 2026Article
- Mentalization and Emotion Regulation in Adolescent Attachment: A Scoping Review.Children (Basel, Switzerland) · 2026Review
- 'They really want to find some kind of box they can put you in': how young people with severe mental health problems and complex needs talk about their past treatment in traditional child and adolescent mental health services - a critical discourse analysis.Frontiers in psychiatry · 2026Article
- Recovery-based suicide prevention.Frontiers in psychiatry · 2025Article
- Childhood Trauma as a Risk Factor for High Risk Behaviors in Adolescents with Borderline Personality Disorder.Iranian journal of psychiatry · 2023Article
- The Relation between Neuroticism and Non-Suicidal Self-Injury Behavior among College Students: Multiple Mediating Effects of Emotion Regulation and Depression.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auto-aggressive behaviour, especially treatment refractory suicidality in adolescents with psychiatric disorders, may be challenging to clinicians. In search of therapeutic possibilities, we have integrated current opinions regarding causality and interdependency of suicidality and auto-aggressive behaviour across disorders within the HiTOP framework. We propose a developmental model regarding these unsettling behaviours in youths that may help to guide future directions for research and interventions. We argue that the interdependent development of biologic factors, attachment, moral reasoning and emotion regulation in an overprotective environment may lead to social anxiety and later during development to emotion dysregulation and severe internalizing behaviour disorders. To optimize treatment efficacy for both internalizing and externalizing behaviour, we emphasize the importance transdiagnostic interventions, such as addressing non-compliance, restoration of trust between parents and their child, and limitation of avoidance behaviour. These may be seen as higher order interventions within the HiTOP framework.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.