ArticleSurgical endoscopy2021
Laparoscopic major hepatectomy for hepatocellular carcinoma in elderly patients: a multicentric propensity score‑based analysis.
Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04852211 (Asia-Pacific Multi-Centre Randomized Trial of Laparoscopic Versus Open Major Hepatectomy for Hepatocellular Carcinoma), which is not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Asia-Pacific Multi-Centre Randomized Trial of Laparoscopic Versus Open Major Hepatectomy for Hepatocellular Carcinoma (AP-LAPO Trial)
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults.Surgical endoscopy · 2024Guideline
- Comparison of survival and post-operation outcomes for minimally invasive versus open hepatectomy in hepatocellular carcinoma: A systematic review and meta-analysis of case-matched studies.Frontiers in oncology · 2022Pooled it
- Laparoscopic versus open hepatectomy for malignant liver tumours in the elderly: systematic review and meta-analysis.Updates in surgery · 2021Pooled it
- Survival analysis between laparoscopic and open hepatectomy for hepatocellular carcinoma: a meta-analysis based on reconstructed time-to-event data.Hepatology international · 2021Pooled it
- Efficacy of Laparoscopic HepatectomyFrontiers in oncology · 2021Pooled it
- Asia-Pacific multicentre randomized trial of laparoscopic versus open major hepatectomy for hepatocellular carcinoma (AP-LAPO trial).BJS open · 2023Trial
- Robotic versus laparoscopic liver resection for intrahepatic cholangiocarcinoma in elderly patients: a multicentre propensity-weighted analysis.Surgical endoscopy · 2026Article
- Feasibility of robotic liver resection compared with laparoscopic and open liver resection for hepatocellular carcinoma: a network meta-analysis.International journal of surgery (London, England) · 2026Article
- A Technique for Laparoscopic Right Hepatectomy Following Portal Vein Embolization in a Patient With Portal Vein Thrombosis: A Case Report.Clinical case reports · 2026Article
- Laparoscopic versus open liver resection in patients aged at least 80 years: retrospective propensity score-matched cohort study.BJS open · 2025Article
- Comparison of robotic liver resection in obese vs. non-obese patients: a multicentric propensity score-matched analysis of perioperative outcomes.Updates in surgery · 2025Article
- Laparoscopic versus open right hepatectomy for colorectal liver metastases after portal vein embolization: international multicentre study.The British journal of surgery · 2024Article
- Comparing laparoscopic and open resection in elderly hepatocellular carcinoma: a systematic review and meta-analysis.Journal of gastrointestinal oncology · 2024Article
- Safety of advanced laparoscopic hepatectomy for elderly patients: a Japanese nationwide analysis.Surgical endoscopy · 2024Article
- Robotic Major Hepatectomy in Elderly Patient.Cancers · 2024Article
- Clinical feasibility of laparoscopic left lateral segment liver resection with magnetic anchor technique: The first clinical study from China.World journal of gastrointestinal surgery · 2024Article
- Minimally invasive versus open liver resection for hepatocellular carcinoma: a propensity score matching analysis of 224 patients.Langenbeck's archives of surgery · 2023Article
- Impact of body mass index in elderly patients treated with laparoscopic liver resection for hepatocellular carcinoma.World journal of gastrointestinal surgery · 2023Article
- Long-term outcomes of laparoscopic liver resection versus open liver resection for hepatocellular carcinoma: A single-center 10-year experience.Frontiers in oncology · 2023Article
- Trocar layouts in laparoscopic liver surgery.Surgical endoscopy · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsidering the increase in overall life expectancy and the rising incidence of hepatocellular carcinoma (HCC), more elderly patients are considered for hepatic resection. Traditionally, major hepatectomy has not been proposed to the elderly due to severe comorbidities. Indeed, only a few case series are reported in the literature. The present study aimed to compare short-term and long-term outcomes between laparoscopic major hepatectomy (LMH) and open major hepatectomy (OMH) in elderly patients with HCC using propensity score matching (PSM).
methodsWe performed a multicentric retrospective study including 184 consecutive cases of HCC major liver resection in patients aged ≥ 70 years in _8 European Hospital Centers. Patients were divided into LMH and OMH groups, and perioperative and long-term outcomes were compared between the 2 groups.
resultsAfter propensity score matching, 122 patients were enrolled, 38 in the LMH group and 84 in the OMH group. Postoperative overall complications were lower in the LMH than in the OMH group (18 vs. 46%, p < 0.001). Hospital stay was shorter in the LMH group than in the OMH group (5 vs. 7 days, p = 0.01). Mortality at 90 days was comparable between the two groups. There were no significant differences between the two groups in terms of overall survival (OS) and disease-free survival (DFS) at 1, 3, and 5 years.
conclusionLMH for HCC is associated with appropriate short-term outcomes in patients aged ≥ 70 years as compared to OMH. LMH is safe and feasible in elderly patients with HCC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.