Evidence map›Paper›PMID 32748030›Full record

ArticlePsychopharmacology2020

Chronic exposure to cocaine is associated with persistent behavioral disturbances. A cross-sectional dimensional study in outpatients with multiple substance use disorders.

Florence Vorspan, Pauline de Witt, El-Hadi Zerdazi, Emily Karsinti, Kamilia Ksouda, Romain Icick, Frank Bellivier, Nicolas Marie, Georges Brousse, Vanessa Bloch

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Drug addiction: from bench to bedside.Translational psychiatry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Florence VorspanDépartement de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique - Hôpitaux de Paris, 200 rue du Faubourg Saint Denis, 75010, Paris, France. florence.vorspan@aphp.fr.ORCID http://orcid.org/0000-0001-5168-3727
Pauline de WittInserm UMR-S 1144 Therapeutic Optimization in Neurosychopharmacology, Université de Paris, Paris, France.
El-Hadi ZerdaziInserm UMR-S 1144 Therapeutic Optimization in Neurosychopharmacology, Université de Paris, Paris, France.
Emily KarsintiDépartement de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique - Hôpitaux de Paris, 200 rue du Faubourg Saint Denis, 75010, Paris, France.
Kamilia KsoudaFaculté de Médecine de Sfax, Sfax, Tunisia.
Romain IcickDépartement de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique - Hôpitaux de Paris, 200 rue du Faubourg Saint Denis, 75010, Paris, France.
Frank BellivierDépartement de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique - Hôpitaux de Paris, 200 rue du Faubourg Saint Denis, 75010, Paris, France.
Nicolas MarieInserm UMR-S 1124, "Environmental Toxicity, Therapeutic Targets, Cellular Signaling and Biomarkers", Université de Paris, Paris, France.
Georges BrousseInserm Umr 1107, Neuro-Dol, Université Clermont-Auvergne, Clermont-Ferrand, France.
Vanessa BlochInserm UMR-S 1144 Therapeutic Optimization in Neurosychopharmacology, Université de Paris, Paris, France.
Inserm · FRCentre National de la Recherche Scientifique · FRUniversity of Sfax · TN

Funding

Direction de la Recherche et de l'Innovation (APHP) OST07013European Commission ADIKHUMICE (ERA-NET Neuron 2017, ANR-17-NEU3-0002-05European Commission : COCAch (ERA-NET Neuron 2013, ANR-13European Commission () COCACE (ERA-NET Neuron 2014, ANR R14026KK)Labex BioPSY (FR) ANR-11-IDEX-0004-02Ministère Français de la Recherche, Programme Hospitalier de Recherche Cliniqu AOM10165
6 · The paper itself

Abstract

rationaleBehavioral disturbances (BD) are prevalent in patients with substance use disorders (SUD).

objectivesTo test the hypothesis that chronic exposure to cocaine could favor the acquisition of BD that were not present in childhood.

methodsWe used child and adult ADHD self-report screening scales (WURS-25 and ASRS-6, respectively, with their usual threshold) as assessment tools for significant BD. In a cross-sectional assessment of 382 patients with multiple SUD, we investigated BD and then "de novo" BD (i.e., by restricting the sample to patients below the threshold for childhood BD) (N = 214). We also tested for a gradient effect between patients' lifetime DSM IV cocaine and opioid dependence status and the prevalence of BD.

resultsBD were found in 188/382 (42.9%) subjects and in 74/214 (34.6%) subjects. Three clinical factors were associated with BD in the whole sample: the number of cocaine dependence criteria (OR = 1.36 [1.14-1.64], p = 0.001), the number of opioid dependence criteria (OR = 0.69 [0.52-0.91], p = 0.010), and a personal history of using cocaine through rapid routes of administration (OR = 0.41 [0.19-0.88], p = 0.022). The same three factors were associated with "de novo" BD in the restricted sample: OR = 1.35 ([1.11-1.63], p = 0.002), OR = 0.83 ([0.70-0.99], p = 0.046), and OR 0.37 ([0.16-0.86], p = 0.022), respectively. There were significant gradients for BD according to the cocaine exposure categories in the whole (Mantel-Haenszel, p < 0.001) and in the restricted sample (Mantel-Haenszel, p = 0.002).

conclusionsCocaine exposure was positively associated with behavioral disturbances in a dose-dependent manner in this clinical sample, whilst opioid exposure showed a negative association.

Indexed as

OutpatientsAdultAmbulatory CareCocaineCocaine-Related DisordersCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMental DisordersMiddle AgedRisk FactorsSubstance-Related DisordersYoung AdultCocaineADHDBehavioral sensitizationCocaineHumanOpioidsScalesScreening

Identifiers

PMID32748030
OpenAlexW3047044854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.