SynthesisEuropean journal of pediatrics2021
Management of pain in newborn circumcision: a systematic review.
Synthesis in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05233683 (Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- [Evidence-based guideline for neonatal pain management in China (2023)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Guideline
- Local anesthetic techniques for analgesia in neonatal circumcision: a network meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Clinic-based Treatment of Type B Ulnar Polydactyly Saves Costs Compared With Treatment in the Operating Room.Plastic and reconstructive surgery. Global open · 2026Article
- Evaluation of the Knowledge Level and Attitudes of Family Physicians Regarding Circumcision: A Cross-sectional Study.Rwanda journal of medicine and health sciences · 2026Article
- Efficiency and Patient Satisfaction of Local Anesthesia Use in Surgical Circumcision in Adults-A Retrospective Cohort Study.BioMed research international · 2026Article
- Improving pain score and restraint duration during circumcision.Journal of family medicine and primary care · 2025Article
- Parental Assessment of Postsurgical Pain in Infants at Home Using Artificial Intelligence-Enabled and Observer-Based Tools: Construct Validity and Clinical Utility Evaluation Study.JMIR pediatrics and parenting · 2024Article
- Psychological, psychosocial, and psychosexual aspects of penile circumcision.International journal of impotence research · 2023Review
- Neonatal Infant Pain Scale in assessing pain and pain relief for newborn male circumcision.International journal of impotence research · 2023Review
- Association of volatile anesthesia exposure and depth with emergence agitation and delirium in children: Prospective observational cohort study.Frontiers in pediatrics · 2023Article
- Efficacy and safety of non-pharmacological interventions for neonatal pain: an overview of systematic reviews.BMJ open · 2022Review
- Systematic review of complications arising from male circumcision.BJUI compass · 2022Review
- [175 years of anesthesia and narcosis-Towards a "human right to unconsciousness"].Der Anaesthesist · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male circumcision (MC) is one of the most common surgical procedures performed on neonates. In the last decades, there have been consistent advances in the understanding of pain mechanisms in newborns, and analgesia has become a fundamental part of neonatal care. MC is still often performed with inappropriate analgesic methods, and there is still great variability among the various centers about surgical and anesthethic techniques to do it. The purpose of this review is to summarize the findings in the literature about pain management and analgesia during newborn MC. We performed a systematic review of neonatal MC studies published in the last 20 years. The most effective technique appeared to be the combination of pharmacological and non-pharmacological methods of analgesia.Conclusion: Combining local anesthesia with non-pharmacological analgesic strategies appears to be effective preventing procedural pain during MC. However, a standardized protocol for analgesia during MC is yet to be determined. Sensorial saturation appeared to help when used in conjunction with the local anesthesia techniques. What is Known: • Male circumcision is a painful procedure and it is frequently performed with inappropriate analgesic methods. • A gold standard practice in analgesia during male circumcision is still lacking and there is a great variability in the modus operandi between centers. What is New: • The combination of RB + EMLA + sucrose appears to be an analgesic strategy superior to other approaches. • We advocate for the integration of sensorial saturation during male circumcision in order to improve the efficacy of current analgesic practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.