ArticleJournal of neurology2021
Impaired naming performance in temporal lobe epilepsy: language fMRI responses are modulated by disease characteristics.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy.Frontiers in neurology · 2022Pooled it
- Contralateral language network integration predicts and protects against naming decline after temporal lobe resection.Epilepsia · 2026Article
- Dynamic and Static Functional Gradient in Temporal Lobe Epilepsy With Hippocampal Sclerosis Versus Healthy Controls.CNS neuroscience & therapeutics · 2025Article
- Memory-guided perception is shaped by dynamic two-stage theta- and alpha-mediated retrieval.Annals of the New York Academy of Sciences · 2025Article
- Long-term neuroplasticity in language networks after anterior temporal lobe resection.Epilepsia · 2025Article
- Naming fMRI-guided white matter language tract volumes influence naming decline after temporal lobe resection.Journal of neurology · 2024Article
- Processing of auditory novelty in human cortex during a semantic categorization task.Hearing research · 2024Article
- Neurological update: structural and functional imaging in epilepsy surgery.Journal of neurology · 2023Review
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- Episodic memory network connectivity in temporal lobe epilepsy.Epilepsia · 2022Article
- Review
- Advanced neuroimaging techniques in epilepsy.Current opinion in neurology · 2022Review
- The importance of basal-temporal white matter to pre- and post-surgical naming ability in temporal lobe epilepsy.NeuroImage. Clinical · 2022Article
- Resection of dominant fusiform gyrus is associated with decline of naming function when temporal lobe epilepsy manifests after the age of five: A voxel-based lesion-symptom mapping study.NeuroImage. Clinical · 2022Article
- Decoupling of functional and structural language networks in temporal lobe epilepsy.Epilepsia · 2021Article
- Combining Gamma With Alpha and Beta Power Modulation for Enhanced Cortical Mapping in Patients With Focal Epilepsy.Frontiers in human neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate alterations of language networks and their relation to impaired naming performance in temporal lobe epilepsy (TLE) using functional MRI.
methodsSeventy-two adult TLE patients (41 left) and 36 controls were studied with overt auditory and picture naming fMRI tasks to assess temporal lobe language areas, and a covert verbal fluency task to probe frontal lobe language regions. Correlation of fMRI activation with clinical naming scores, and alteration of language network patterns in relation to epilepsy duration, age at onset and seizure frequency, were investigated with whole-brain multiple regression analyses.
resultsAuditory and picture naming fMRI activated the left posterior temporal lobe, and stronger activation correlated with better clinical naming scores. Verbal fluency MRI mainly activated frontal lobe regions. In left and right TLE, a later age of epilepsy onset related to stronger temporal lobe activations, while earlier age of onset was associated with impaired deactivation of extratemporal regions. In left TLE patients, longer disease duration and higher seizure frequency were associated with reduced deactivation. Frontal lobe language networks were unaffected by disease characteristics.
conclusionsWhile frontal lobe language regions appear spared, temporal lobe language areas are susceptible to dysfunction and reorganisation, particularly in left TLE. Early onset and long duration of epilepsy, and high seizure frequency, were associated with compromised activation and deactivation patterns of task-associated regions, which might account for impaired naming performance in individuals with TLE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.