ArticleNature neuroscience2020
Active dendritic currents gate descending cortical outputs in perception.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 241 citations in OpenAlex.
- The Central Medial Thalamus Serves as a Critical Hub for Preserved Arousability During Dexmedetomidine Sedation.Neuroscience bulletin · 2026Article
- A cortical output channel for perceptual categorization.Science advances · 2026Article
- Thalamocortical bursts encode reward contingencies and drive associative learning.Nature communications · 2026Article
- Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication.bioRxiv : the preprint server for biology · 2026Article
- Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures.Molecular psychiatry · 2026Article
- Localized Temperature Monitoring in Mouse Brain during Light Delivery via a Non-Planar Tapered Fiber-Integrated µRTD Sensor.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- Anterior lateral motor cortex enables contextual decision-making via dynamic reconfiguration of local circuits.Cell reports · 2026Article
- Somatosensory cortex shapes perceptual decision bias via the superior colliculus.Research square · 2026Article
- Conscious and nonconscious thought: Insights from the neuroscience of decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A shared predictive architecture in the sensory cortex for statistical and reward-based learning.Current opinion in neurobiology · 2026Review
- Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.Nature communications · 2026Article
- Perirhinal input to auditory cortex supports memory-guided sensory perception.Science advances · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Anesthetic State-Dependent Bidirectional Control of States of Consciousness via Heterogeneous Medial Septum to Ventral Tegmental Area Circuits under Sevoflurane in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Distinct roles of cortical layer 5 subtypes in associative learning.Nature communications · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Presynaptic control of top-down signaling in neocortical layer 1.bioRxiv : the preprint server for biology · 2026Article
- An adaptive and flexible role for primary sensory cortex.Nature neuroscience · 2026Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical dendrites of layer 5 (L5) pyramidal neurons correlates with the threshold for perception, but these neurons come in two classes that target either other cortical or subcortical areas. In the present study, we took advantage of transgenic mouse lines for these L5 subclasses to determine their relative contributions to the perceptual process. We found that the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice. Our results suggest that dendritic activation drives context-dependent interactions between cortex and subcortical regions, including the higher-order thalamus, superior colliculus and striatum, which are crucial for perception.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.