ArticleNature chemistry2020
Knotting a molecular strand can invert macroscopic effects of chirality.
Article in Nature chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Programmable Helical Periodicity in Single-Component Supramolecular Nanofibers for Pitch-Regulated Cellular Response.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Energy Landscapes of Model Knotted Polymers.Journal of chemical theory and computation · 2025Article
- Discovery of an Interlocked and Interwoven Molecular Topology in Nanocarbons via Dynamic C-C Bond Formation.Journal of the American Chemical Society · 2025Article
- Phosphorescent metallaknots of Au(I)-bis(acetylide) strands directed by Cu(I) π-coordination.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Folding a Molecular Strand into a Trefoil Knot of Single Handedness with Co(II)/Co(III) Chaperones.Journal of the American Chemical Society · 2024Article
- Mechanical scission of a knotted polymer.Nature chemistry · 2024Article
- Knot Formation on DNA Pushed Inside Chiral Nanochannels.Polymers · 2023Article
- Macroscopic handedness inversion of terbium coordination polymers achieved by doping homochiral ligand analogues.Chemical science · 2023Article
- The Story of the Little Blue Box: A Tribute to Siegfried Hünig.Angewandte Chemie (International ed. in English) · 2023Review
- Directing the Self-Assembly of Aromatic Foldamer Helices using Acridine Appendages and Metal Coordination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Article
- Knotting matters: orderly molecular entanglements.Chemical Society reviews · 2022Review
- Untangling knotty problems.Nature chemistry · 2021Article
- A molecular endless (7Nature chemistry · 2021Article
- Effects of turn-structure on folding and entanglement in artificial molecular overhand knots.Chemical science · 2020Article
- Open questions in functional molecular topology.Communications chemistry · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transferring structural information from the nanoscale to the macroscale is a promising strategy for developing adaptive and dynamic materials. Here we demonstrate that the knotting and unknotting of a molecular strand can be used to control, and even invert, the handedness of a helical organization within a liquid crystal. An oligodentate tris(2,6-pyridinedicarboxamide) strand with six point-chiral centres folds into an overhand knot of single handedness upon coordination to lanthanide ions, both in isotropic solutions and in liquid crystals. In achiral liquid crystals, dopant knotted and unknotted strands induce supramolecular helical organizations of opposite handedness, with dynamic switching achievable through in situ knotting and unknotting events. Tying the molecular knot transmits information regarding asymmetry across length scales, from Euclidean point chirality (constitutional chirality) via molecular entanglement (conformation) to liquid-crystal (centimetre-scale) chirality. The magnitude of the effect induced by the tying of the molecular knots is similar to that famously used to rotate a glass rod on the surface of a liquid crystal by synthetic molecular motors.
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Registered trials
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