ArticleScientific reports2020
The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Long-Term Culturing of Placozoans (Trichoplax and Hoilungia).Methods in molecular biology (Clifton, N.J.) · 2024Article
- Brief History of Placozoa.Methods in molecular biology (Clifton, N.J.) · 2024Review
- The ancestral architecture of the immune system in simplest animals.Frontiers in immunology · 2024Article
- Parallel evolution of gravity sensing.Frontiers in cell and developmental biology · 2024Article
- Neuronal gene expression in two generations of the marine parasitic worm, Cryptocotyle lingua.Communications biology · 2023Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
- What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals.Animal cognition · 2023Review
- Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates.International journal of molecular sciences · 2023Review
- Nitric oxide suppresses cilia activity in ctenophores.bioRxiv : the preprint server for biology · 2023Article
- Recording cilia activity in ctenophores: effects of nitric oxide and low molecular weight transmitters.Frontiers in neuroscience · 2023Article
- Nitric oxide signaling in ctenophores.Frontiers in neuroscience · 2023Article
- Exaptation and Evolutionary Adaptation in Nociceptor Mechanisms Driving Persistent Pain.Brain, behavior and evolution · 2023Review
- Amino acids integrate behaviors in nerveless placozoans.Frontiers in neuroscience · 2023Article
- The Evolution of Nitric Oxide Function: From Reactivity in the Prebiotic Earth to Examples of Biological Roles and Therapeutic Applications.Antioxidants (Basel, Switzerland) · 2022Review
- Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis.International journal of molecular sciences · 2022Article
- Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans).Frontiers in cell and developmental biology · 2022Article
- Expanding of Life Strategies in Placozoa: Insights From Long-Term Culturing ofFrontiers in cell and developmental biology · 2022Article
- Evolution of glutamatergic signaling and synapses.Neuropharmacology · 2021Review
- Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis.Cell and tissue research · 2021Article
- The American lobster genome reveals insights on longevity, neural, and immune adaptations.Science advances · 2021Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a ubiquitous gaseous messenger, but we know little about its early evolution. Here, we analyzed NO synthases (NOS) in four different species of placozoans-one of the early-branching animal lineages. In contrast to other invertebrates studied, Trichoplax and Hoilungia have three distinct NOS genes, including PDZ domain-containing NOS. Using ultra-sensitive capillary electrophoresis assays, we quantified nitrites (products of NO oxidation) and L-citrulline (co-product of NO synthesis from L-arginine), which were affected by NOS inhibitors confirming the presence of functional enzymes in Trichoplax. Using fluorescent single-molecule in situ hybridization, we showed that distinct NOSs are expressed in different subpopulations of cells, with a noticeable distribution close to the edge regions of Trichoplax. These data suggest both the compartmentalized release of NO and a greater diversity of cell types in placozoans than anticipated. NO receptor machinery includes both canonical and novel NIT-domain containing soluble guanylate cyclases as putative NO/nitrite/nitrate sensors. Thus, although Trichoplax and Hoilungia exemplify the morphologically simplest free-living animals, the complexity of NO-cGMP-mediated signaling in Placozoa is greater to those in vertebrates. This situation illuminates multiple lineage-specific diversifications of NOSs and NO/nitrite/nitrate sensors from the common ancestor of Metazoa and the preservation of conservative NOS architecture from prokaryotic ancestors.
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