Observational studyScientific reports2020
A new novel method for assessing intracranial pressure using non-invasive fundus images: a pilot study.
Observational study in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03382860 (Estimation of Intracranial Pressure Using Non-invasive Fundus Videos), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Estimation of Intracranial Pressure Using Non-invasive Fundus Videos
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Non-invasive fundoscopy as a tool to estimate intracranial pressure: a large animal model.Acta neurochirurgica · 2025Article
- Fundoscopy as a diagnostic biomarker in idiopathic normal pressure hydrocephalus: a pilot study.BMJ neurology open · 2025Article
- Utilizing retinal arteriole/venule ratio to estimate intracranial pressure.Acta neurochirurgica · 2024Article
- Non-invasive assessment of intracranial pressure through the eyes: current developments, limitations, and future directions.Frontiers in neurology · 2024Review
- Cerebral malaria-using the retina to study the brain.Eye (London, England) · 2023Review
- Non-Invasive Intracranial Pressure Monitoring.Journal of clinical medicine · 2023Review
- A Review of the Methods of Non-Invasive Assessment of Intracranial Pressure through Ocular Measurement.Bioengineering (Basel, Switzerland) · 2022Review
- Noninvasive Estimation of Pulsatile and Static Intracranial Pressure by Optical Coherence Tomography.Translational vision science & technology · 2022Article
- A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography.PloS one · 2022Article
- Linear interactions between intraocular, intracranial pressure, and retinal vascular pulse amplitude in the fourier domain.PloS one · 2022Article
- The application value of CT radiomics features in predicting pressure amplitude correlation index in patients with severe traumatic brain injury.Frontiers in neurology · 2022Article
- Beyond pressure: intracranial compliance and retinal biomarkers in idiopathic normal pressure hydrocephalus.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arteriole and venule diameter ratio (A/V-ratio) can be measured using fundus photography. In this pilot study, we correlated changes in the intracranial pressure with the diameter of vessels of the retina. We investigated whether increased intracranial pressure (ICP) was reflected in a measurable and quantifiable distention of the venule diameter, leading to a decreased A/V-ratio. This was demonstrated by assessment of the A/V-ratio in patients already undergoing conventional ICP monitoring with a cerebral intraparenchymal pressure monitor. Our method shows a correlation between A/V ratio and ICP and suggests an easily obtainable and usable point-of-care (POC), non-invasive method to estimate the intracranial pressure without the necessity of mydriatic drugs. Furthermore, the sensitivity/specificity analysis with a cut-off of < 0.8015 A/V-ratio, showed a sensitivity of 94% [85-98%] and a specificity of 50% [34-66%] with a positive likelihood ratio of 9.0. This means that in a clinical setting there is a 94% chance of correctly identifying individuals with ICP ≥ 20 mmHg.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.