ArticleScientific reports2020
Associations of PRKN-PACRG SNPs and G × G and G × E interactions with the risk of hyperlipidaemia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design.Biomedicines · 2025Article
- Association between the EHBP1 SNPs and dyslipidemia in the end-stage renal disease patients with dialysis in Chinese Han population.Lipids in health and disease · 2024Article
- Mutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach.Molecular psychiatry · 2024Article
- Effects ofFrontiers in cardiovascular medicine · 2022Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
This research aimed to assess the associations of 7 parkin RBR E3 ubiquitin protein ligase (PRKN) and 4 parkin coregulated gene (PACRG) single-nucleotide polymorphisms (SNPs), their haplotypes, gene-gene (G × G) and gene-environment (G × E) interactions with hyperlipidaemia in the Chinese Maonan minority. The genotypes of the 11 SNPs in 912 normal and 736 hyperlipidaemic subjects were detected with next-generation sequencing technology. The genotypic and allelic frequencies of the rs1105056, rs10755582, rs2155510, rs9365344, rs11966842, rs6904305 and rs11966948 SNPs were different between the normal and hyperlipidaemic groups (P < 0.05-0.001). Correlations between the above 7 SNPs and blood lipid levels were also observed (P < 0.0045-0.001, P < 0.0045 was considered statistically significant after Bonferroni correction). Strong linkage disequilibrium was found among the 11 SNPs (r
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