Evidence map›Paper›PMID 32747566›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates.

Jessika C Bridi, Zoe N Ludlow, Benjamin Kottler, Beate Hartmann, Lies Vanden Broeck, Jonah Dearlove, Markus Göker, Nicholas J Strausfeld, Patrick Callaerts, Frank Hirth

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Jessika C BridiDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9RT, United Kingdom.
Zoe N LudlowDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9RT, United Kingdom.
Benjamin KottlerDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9RT, United Kingdom.ORCID 0000-0002-4551-5791
Beate HartmannUniversity of Basel, 4031 Basel, Switzerland.
Lies Vanden BroeckLaboratory of Behavioural & Developmental Genetics, Department of Human Genetics, Katholieke Universiteit Leuven, 6023000 Leuven, Belgium.
Jonah DearloveDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9RT, United Kingdom.
Markus GökerLeibniz Institute German Collection of Microorganisms and Cell Cultures, 38124 Braunschweig, Germany.
Nicholas J StrausfeldDepartment of Neuroscience, University of Arizona, Tucson, AZ 85721; Frank.Hirth@kcl.ac.uk flybrain@arizona.edu.ORCID 0000-0002-1115-1774
Patrick CallaertsLaboratory of Behavioural & Developmental Genetics, Department of Human Genetics, Katholieke Universiteit Leuven, 6023000 Leuven, Belgium.
Frank HirthDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9RT, United Kingdom; Frank.Hirth@kcl.ac.uk flybrain@arizona.edu.ORCID 0000-0001-8581-9450
King's College London · GBKU Leuven · BELeibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures · DEUniversity of Arizona · USUniversity of Basel · CH

Funding

Biotechnology and Biological Sciences Research Council BB/N001230/1Medical Research Council G0701498Medical Research Council MR/L010666/1Motor Neurone Disease Association HIRTH/MAR12/6085Motor Neurone Disease Association HIRTH/OCT07/6233Motor Neurone Disease Association HIRTH/OCT13/868-792Motor Neurone Disease Association HIRTH/OCT16/890-792Parkinson's UK G-0714
6 · The paper itself

Abstract

Corresponding attributes of neural development and function suggest arthropod and vertebrate brains may have an evolutionarily conserved organization. However, the underlying mechanisms have remained elusive. Here, we identify a gene regulatory and character identity network defining the deutocerebral-tritocerebral boundary (DTB) in

Indexed as

Evolution, MolecularGene Regulatory NetworksAnimalsBehavior, AnimalBrainDrosophilaFibroblast Growth Factor 8Gene Expression Regulation, DevelopmentalHumansMesencephalonMiceNerve Tissue ProteinsNeural PathwaysPaired Box Transcription FactorsRegulatory Sequences, Nucleic AcidRhombencephalonFibroblast Growth Factor 8Nerve Tissue ProteinsPaired Box Transcription Factorsbrainevolutiongene regulatory networkhomologyneural circuit

Identifiers

PMID32747566
PMCPMC7431035
OpenAlexW3047102082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.