ArticleProceedings of the National Academy of Sciences of the United States of America2020
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 91 citations in OpenAlex.
- Zika virus positivity in Aedes aegypti mosquitoes and its genomic landscape from Pune, Western India.The Indian journal of medical research · 2026Article
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- Breaking barriers and beyond: Mechanisms and pathological implications of Zika virus traversal across blood-tissue interfaces.Virologica Sinica · 2026Review
- Tembusu virus neuroinvasion and neuropathogenesis: lessons from blood-brain barrier dysfunction in neurotropic flaviviruses.Frontiers in veterinary science · 2026Review
- Vertical Transmission of Zika Virus: The Immune-Pathophysiological Interface of the Placenta.Journal of immunology research · 2026Review
- Comparison of human cerebral organoids infected with wild-type Zika versus attenuated DN-2 virus strains uncovers differences in host immune responses.Cell communication and signaling : CCS · 2025Article
- Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025Review
- Manipulating Zika virus RNA tertiary structure for developing tissue-specific attenuated vaccines.EMBO molecular medicine · 2025Article
- Building a growing genomic repository for maternal and fetal health through the PING Consortium.Pediatric research · 2025Article
- ZIKA Virus, an Emerging Arbovirus in India: A Glimpse of Global Genetic Lineages.Microorganisms · 2025Review
- Is the Zika virus re-emerging as a distinct genetic lineage in India?Access microbiology · 2025Article
- Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity.Nature communications · 2024Article
- An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.Journal of virology · 2024Article
- Article
- Envelope domain III EJournal of virology · 2024Article
- Zika viruses encode 5' upstream open reading frames affecting infection of human brain cells.Nature communications · 2024Article
- Zika Virus-A Reemerging Neurotropic Arbovirus Associated with Adverse Pregnancy Outcomes and Neuropathogenesis.Pathogens (Basel, Switzerland) · 2024Review
- Genomic variability in Zika virus in GBS cases in Colombia.PloS one · 2024Article
- Mutations in SARS-CoV-2 variant nsp6 enhance type-I interferon antagonism.Emerging microbes & infections · 2023Article
- Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages.Emerging microbes & infections · 2023Article
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
Arboviruses maintain high mutation rates due to lack of proofreading ability of their viral polymerases, in some cases facilitating adaptive evolution and emergence. Here we show that, just before its 2013 spread to the Americas, Zika virus (ZIKV) underwent an envelope protein V473M substitution (E-V473M) that increased neurovirulence, maternal-to-fetal transmission, and viremia to facilitate urban transmission. A preepidemic Asian ZIKV strain (FSS13025 isolated in Cambodia in 2010) engineered with the V473M substitution significantly increased neurovirulence in neonatal mice and produced higher viral loads in the placenta and fetal heads in pregnant mice. Conversely, an epidemic ZIKV strain (PRVABC59 isolated in Puerto Rico in 2015) engineered with the inverse M473V substitution reversed the pathogenic phenotypes. Although E-V473M did not affect oral infection of
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