Evidence map›Paper›PMID 32747560›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders.

Yi Zhang, Yunliang Guan, Susu Pan, Lihong Yan, Ping Wang, Zhuo Chen, Qing Shen, Faming Zhao, Xin Zhang, Juan Li and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. DNA-Assisted Assays for Studying Lipid Transfer Between Membranes.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Article
  7. The Hypothalamic Epigenetic Landscape in Dietary Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Yi ZhangDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Yunliang GuanDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Susu PanDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Lihong YanState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Ping WangDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Zhuo ChenDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Qing ShenDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Faming ZhaoDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Xin ZhangState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Juan LiDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Juxue LiState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China; lijuxue@njmu.edu.cn dongsheng.cai@einstein.yu.edu gzhang@hust.edu.cn.
Dongsheng CaiDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461 lijuxue@njmu.edu.cn dongsheng.cai@einstein.yu.edu gzhang@hust.edu.cn.
Guo ZhangDepartment of Toxicology, Key Laboratory of Environmental Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; lijuxue@njmu.edu.cn dongsheng.cai@einstein.yu.edu gzhang@hust.edu.cn.ORCID 0000-0002-3880-6996
Huazhong University of Science and Technology · CNAlbert Einstein College of Medicine · USNanjing Medical University · CN

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

The C

Indexed as

AnimalsDiet, High-FatGene Expression RegulationGenetic Predisposition to DiseaseHypothalamusMaleMiceMice, KnockoutNeuronsObesityProprotein Convertase 1Proprotein Convertase 2SynaptotagminsEsyt3 protein, mouseProprotein Convertase 1Proprotein Convertase 2Synaptotagminsextended synaptotagmin 3glucose intolerancehypothalamusobesityPOMC neuron

Identifiers

PMID32747560
PMCPMC7443966
OpenAlexW3047104649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.