Evidence map›Paper›PMID 32747542›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Alternative splicing of DSP1 enhances snRNA accumulation by promoting transcription termination and recycle of the processing complex.

Weili Wang, Xuepiao Pu, Siyu Yang, Yujie Feng, Chan Lin, Mu Li, Xi Li, Huali Li, Chunmei Meng, Qingjun Xie and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Weili WangState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, 530004 Nanning, Guangxi, China.ORCID 0000-0002-4127-3131
Xuepiao PuState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, 530004 Nanning, Guangxi, China.
Siyu YangState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, 530004 Nanning, Guangxi, China.
Yujie FengState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, 530004 Nanning, Guangxi, China.
Chan LinState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, 530004 Nanning, Guangxi, China.
Mu LiCenter for Plant Science Innovation and School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0660.
Xi LiState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, South China Agricultural University, 510642 Guangzhou, China.
Huali LiState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, South China Agricultural University, 510642 Guangzhou, China.
Chunmei MengLife Sciences Institute, Guangxi Medical University, 530021 Nanning, China.
Qingjun XieState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, South China Agricultural University, 510642 Guangzhou, China.
Bin YuCenter for Plant Science Innovation and School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0660; byu3@unl.edu yunfengliu_bio@126.com.ORCID 0000-0002-4763-177X
Yunfeng LiuState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, 530004 Nanning, Guangxi, China; byu3@unl.edu yunfengliu_bio@126.com.ORCID 0000-0002-4166-9056
Guangxi University · CNSouth China Agricultural University · CNUniversity of Nebraska–Lincoln · USGuangxi Medical University · CN

Funding

Understand the function of the MOS4-associated complex in microRNA biogenesisR01GM127414 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI YU, BIN · 2018 to 2022
$1.6M
NIGMS NIH HHS R01 GM127414
6 · The paper itself

Abstract

Small nuclear RNAs (snRNAs) are the basal components of the spliceosome and play crucial roles in splicing. Their biogenesis is spatiotemporally regulated. However, related mechanisms are still poorly understood. Defective in snRNA processing (DSP1) is an essential component of the DSP1 complex that catalyzes plant snRNA 3'-end maturation by cotranscriptional endonucleolytic cleavage of the primary snRNA transcripts (presnRNAs). Here, we show that

Indexed as

Alternative SplicingArabidopsisArabidopsis ProteinsGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantGenetic VariationNuclear ProteinsPollenRNA, Small NuclearSeedsArabidopsis ProteinsAT4G20060 protein, ArabidopsisNuclear ProteinsRNA, Small Nuclearalternative splicingDSP1DSP1αsnRNAtranscript termination

Identifiers

PMID32747542
PMCPMC7443885
OpenAlexW3046967685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.