Evidence map›Paper›PMID 32747501›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions.

Satoru Watanabe, Masayuki Fujino, Yohei Saito, Nursarat Ahmed, Hirotaka Sato, Chie Sugimoto, Tomotaka Okamura, Kenichi Hanaki, Emi E Nakayama, Tatsuo Shioda and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Targeting natural killer cells to enhance vaccine responses.Trends in pharmacological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Satoru WatanabeAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Masayuki FujinoAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Yohei SaitoAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.ORCID 0000-0001-6564-6628
Nursarat AhmedAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Hirotaka SatoAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.ORCID 0000-0002-8321-9731
Chie SugimotoDokkyo Medical University, Mibu 321-0293, Japan.ORCID 0000-0002-0488-2931
Tomotaka OkamuraTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba 305-0843, Japan.
Kenichi HanakiDivision of Experimental Animal Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Emi E NakayamaResearch Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0002-0477-0980
Tatsuo ShiodaResearch Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Kouji MatsushimaDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda 278-0022, Japan.
Aftab A AnsariEmory University School of Medicine, Atlanta, GA 30322; and.ORCID 0000-0003-4607-7268
Francois VillingerNew Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70562.ORCID 0000-0002-7790-2008
Kazuyasu MoriAIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; mori@nih.go.jp.ORCID 0000-0002-1841-6376
National Institute of Infectious Diseases · JPThe University of Osaka · JPTokyo University of Science · JPDokkyo Medical University · JPEmory University · USNational Institute of Biomedical Innovation, Health and Nutrition · JPUniversity of Louisiana at Lafayette · US

Funding

Monitoring SIV Reservoirs with Whole Body immunoPETR01AI111907 · NIAID · UNIVERSITY OF LOUISIANA AT LAFAYETTE · PI SANTANGELO, PHILIP J, VILLINGER, FRANCOIS J · 2014 to 2018
$5.8M
Resource for Nonhuman Primate Immune ReagentsR24OD010947 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI VILLINGER, FRANCOIS J · 2012 to 2025
$4.9M
NIAID NIH HHS R01 AI111907NIH HHS R24 OD010947
6 · The paper itself

Abstract

Deglycosylated, live-attenuated SIV vaccines elicited protective immune responses against heterologous SIVsmE543-3, which differs from the vaccine strain SIVmac239 to levels similar to those across HIV-1 clades. Two thirds of the vaccinees contained the chronic SIVsmE543-3 infection (controllers), whereas one third did not (noncontrollers). In this study, we investigated immune correlates of heterologous challenge control in rhesus macaques of Burmese origin. Because depletion of CD8

Indexed as

AnimalsAntibodies, ViralCD8-Positive T-LymphocytesImmunity, InnateInterleukin-15Killer Cells, NaturalMacaca mulattaMaleMonocytesSAIDS VaccinesSignal TransductionSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusVaccinationVaccines, AttenuatedViral LoadAntibodies, ViralInterleukin-15SAIDS VaccinesVaccines, Attenuated

Identifiers

PMID32747501
PMCPMC7484436
OpenAlexW3047270751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.