Evidence map›Paper›PMID 32747449›Full record

ArticleBiology open2020

Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (

Komal Panchal, Anand Krishna Tiwari

Open access · goldAbstract read
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  11. Insights fromFrontiers in neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Komal PanchalGenetics and Developmental Biology Laboratory, Department of Biological Sciences and Biotechnology, Institute of Advanced Research (IAR), Koba, Gandhinagar, Gujarat 382426, India.
Anand Krishna TiwariGenetics and Developmental Biology Laboratory, Department of Biological Sciences and Biotechnology, Institute of Advanced Research (IAR), Koba, Gandhinagar, Gujarat 382426, India aktiwari@iar.ac.in aktiwari@iiar.res.in.ORCID 0000-0002-4080-6653
Indian Institute of Advanced Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Miro (mitochondrial Rho GTPases), a mitochondrial outer membrane protein, facilitates mitochondrial axonal transport along the microtubules to facilitate neuronal function. It plays an important role in regulating mitochondrial dynamics (fusion and fission) and cellular energy generation. Thus, Miro might be associated with the key pathologies of several neurodegenerative diseases (NDs) including Alzheimer's disease (AD). In the present manuscript, we have demonstrated the possible genetic interaction between Miro and AD-related genes such as

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAnimals, Genetically ModifiedCell DeathDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsEctopic Gene ExpressionGene Knockdown TechniquesMembrane ProteinsMitochondriaNerve Tissue ProteinsOxidative StressPeptide FragmentsProtein BindingAmyloid beta-Peptidesamyloid beta-protein (1-42)Appl protein, DrosophilaDrosophila ProteinsMembrane ProteinsMiro protein, DrosophilaNerve Tissue ProteinsPeptide Fragmentsrho GTP-Binding Proteinstau ProteinsAlzheimer's diseaseApplAβ42MiroMitochondriaTau

Identifiers

PMID32747449
PMCPMC7489762
OpenAlexW3046853054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.