Evidence map›Paper›PMID 32747443›Full record

ArticleThe Journal of biological chemistry2020

Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure.

Cody D Smith, Cameron A Schmidt, Chien-Te Lin, Kelsey H Fisher-Wellman, P Darrell Neufer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Peripheral blood mononuclear cell mitochondrial bioenergetics are related to vascular endothelial function in young and older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  5. Article
  6. Obesogens: a unifying theory for the global rise in obesity.International journal of obesity (2005) · 2024
    Review
  7. Review
  8. Reactive oxygen species: role in obesity and mitochondrial energy efficiency.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Regulation of immune cell function by nicotinamide nucleotide transhydrogenase.American journal of physiology. Cell physiology · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. The energetic cost of NNT-dependent ROS removal.The Journal of biological chemistry · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cody D SmithEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
Cameron A SchmidtEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
Chien-Te LinEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
Kelsey H Fisher-WellmanEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
P Darrell NeuferEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA. Electronic address: neuferp@ecu.edu.
East Carolina University · US

Funding

Bioenergetics of Metformin Action and AgingR01AG069679 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NEUFER, P DARRELL · 2020 to 2024
$1.8M
Impact of organic cations on mitochondrial energetic driving forces and metabolic efficiencyR01DK110656 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2016 to 2019
$1.8M
Redox Biology and Muscle Insulin SensitivityR01DK096907 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2012 to 2015
$1.4M
NIA NIH HHS R01 AG069679NIDDK NIH HHS R01 DK096907NIDDK NIH HHS R01 DK110656
6 · The paper itself

Abstract

Compensatory changes in energy expenditure occur in response to positive and negative energy balance, but the underlying mechanism remains unclear. Under low energy demand, the mitochondrial electron transport system is particularly sensitive to added energy supply (

Indexed as

Energy MetabolismOxygen ConsumptionAdenosine DiphosphateAnimalsHydrogen PeroxideMaleMiceMitochondrial ProteinsMitochondria, MuscleNADP Transhydrogenase, AB-SpecificOxidation-ReductionAdenosine DiphosphateHydrogen PeroxideMitochondrial ProteinsNADP Transhydrogenase, AB-SpecificNnt protein, mousebeta-oxidationbioenergeticselectron transport system (ETS)energy metabolismhydrogen peroxide (H2O2)hydrogen sulfidemitochondrial metabolismnicotinamide nucleotide transhydrogenasenicotinamide nucleotide transhydrogenase (NNT)redox buffering circuitsredox regulation

Identifiers

PMID32747443
PMCPMC7705309
OpenAlexW3047544313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.