Evidence map›Paper›PMID 32747384›Full record

ArticleBMJ open diabetes research & care2020

Characterization of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease.

Meera Nair, William P Martin, Vadim Zhernovkov, Jessie A Elliott, Naomi Fearon, Hans Eckhardt, Janet McCormack, Catherine Godson, Eoin Patrick Brennan, Lars Fandriks and 2 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Meera NairDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.
William P MartinDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.ORCID 0000-0001-7005-3966
Vadim ZhernovkovSystems Biology Ireland, Dublin, Ireland.
Jessie A ElliottDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.
Naomi FearonDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.
Hans EckhardtDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.
Janet McCormackResearch Pathology, UCD Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland.
Catherine GodsonDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.
Eoin Patrick BrennanDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.
Lars FandriksInstitute of Clinical Sciences, Salgrenska Academy, University of Gothenburg, Goteborg, Sweden.
Neil G DochertyDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland neil.docherty@ucd.ie.ORCID 0000-0002-0961-2607
Carel W le RouxDiabetes Complications Research Centre, School of Medicine, University College Dublin, Dublin, Ireland.ORCID 0000-0001-5521-5445
University College Dublin · IEUniversity of Gothenburg · SE

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionRoux-en-Y gastric bypass surgery (RYGB) reduces albuminuria and the long-term incidence of end-stage renal disease in patients with obesity and diabetes. Preclinical modeling in experimental diabetic kidney disease demonstrates that improvements in glomerular structure likely underpin these findings. RESEARCH DESIGN AND

methodsIn adult male Zucker diabetic fatty (ZDF) rats, we profiled the effect of RYGB on weight and metabolic control as well biochemical, structural and ultrastructural indices of diabetic renal injury. Furthermore, we sequenced the renal cortical transcriptome in these rats and used bioinformatic pathway analyses to characterize the transcriptional alterations governing the renal reparative response to RYGB.

resultsIn parallel with improvements in weight and metabolic control, RYGB reduced albuminuria, glomerulomegaly, podocyte stress and podocyte foot process effacement. Pathway analysis of RYGB-induced transcriptomic changes in the renal cortex highlighted correction of disease-associated alterations in fibrosis, inflammation and biological oxidation pathways. RYGB reversed disease-associated changes in the expression of transforming growth factor (TGF)-β superfamily genes that strongly correlated with improvements in structural measures of glomerulopathy.

conclusionsImproved glomerular structure in ZDF rats following RYGB is underpinned by pathway level changes, including interruption of the TGF-β-driven early profibrotic programme. Our data provide an important layer of experimental support for clinical evidence demonstrating that RYGB arrests renal damage in patients with obesity and type 2 diabetes.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesGastric BypassAnimalsHumansMaleRatsRats, ZuckerTranscriptomebariatric surgerykidney/glomerulus/pathologyRNA studiesZDF rat(s)

Identifiers

PMID32747384
PMCPMC7398104
OpenAlexW3046419233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.