Evidence map›Paper›PMID 32747363›Full record

ArticleCancer research2020

Endothelin-1-Mediated Drug Resistance in

Inés Pulido, Stephen Ollosi, Salvador Aparisi, Jeffrey H Becker, Alicia Aliena-Valero, Marta Benet, María L Rodríguez, Adrián López, Eva Tamayo-Torres, Lourdes Chuliá-Peris and 16 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Zoological research · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Endothelin and the tumor microenvironment: a finger in every pie.Clinical science (London, England : 1979) · 2024
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 2 countries.

Inés Pulido *Department of Surgery, Division of Cardiothoracic Surgery, University of Illinois at Chicago, Chicago, Illinois.
Stephen Ollosi *Biochemistry and Molecular Biology Program, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Salvador AparisiDepartament de Fisiologia, Facultat de Farmàcia, Universitat de València, Burjassot, Spain.
Jeffrey H BeckerDepartment of Surgery, Division of Cardiothoracic Surgery, University of Illinois at Chicago, Chicago, Illinois.
Alicia Aliena-ValeroDepartament de Fisiologia, Facultat de Farmàcia, Universitat de València, Burjassot, Spain.ORCID 0000-0001-8858-0481
Marta BenetBiomarkers and Precision Medicine Unit and Analytic Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
María L RodríguezDepartament de Fisiologia, Facultat de Farmàcia, Universitat de València, Burjassot, Spain.ORCID 0000-0003-1809-4693
Adrián LópezBiomarkers and Precision Medicine Unit and Analytic Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Eva Tamayo-TorresDepartament de Fisiologia, Facultat de Farmàcia, Universitat de València, Burjassot, Spain.ORCID 0000-0001-9289-5996
Lourdes Chuliá-PerisDepartament de Fisiologia, Facultat de Farmàcia, Universitat de València, Burjassot, Spain.ORCID 0000-0002-0355-8187
Juan Carlos García-CañaverasBiomarkers and Precision Medicine Unit and Analytic Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Margaret SoucherayDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.ORCID 0000-0002-0370-6653
Annika V DalheimDepartment of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Juan B SalomDepartament de Fisiologia, Facultat de Farmàcia, Universitat de València, Burjassot, Spain.ORCID 0000-0002-4162-6101
Wei QiuDepartment of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Simon KajaDepartment of Molecular Pharmacology and Neuroscience, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Javier Alcácer Fernández-CoronadoDepartment of Pathology, Hospital Quirónsalud, Valencia, Spain.
Sandra AlandesDepartment of Pathology, Hospital Quirónsalud, Valencia, Spain.
Javier AlcácerDepartment of Pathology, Hospital Quirónsalud, Valencia, Spain.
Fátima Al-ShahrourBioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0003-2373-769X
Jeffrey A BorgiaDepartment of Cell & Molecular Medicine, Rush University Medical Center, Chicago, Illinois.
Oscar JuanBiomarkers and Precision Medicine Unit and Analytic Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.ORCID 0000-0002-7772-9030
Michael I NishimuraDepartment of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
Agustín LahozBiomarkers and Precision Medicine Unit and Analytic Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.ORCID 0000-0001-7232-0626
Julián CarreteroDepartament de Fisiologia, Facultat de Farmàcia, Universitat de València, Burjassot, Spain. tshima2@uic.edu Julian.carretero@uv.es.ORCID 0000-0001-7269-8506
Takeshi ShimamuraDepartment of Surgery, Division of Cardiothoracic Surgery, University of Illinois at Chicago, Chicago, Illinois. tshima2@uic.edu Julian.carretero@uv.es.
Universitat de València · ESLoyola University Chicago · USInstituto de Investigación Sanitaria La Fe · ESHospital Quirónsalud Barcelona · ESUniversity of Illinois Chicago · USRush University Medical Center · USSpanish National Cancer Research Centre · ES

Funding

TCR TRANSDUCED CDB T CELLS FOR ADOPTIVE IMMUNOTHERAPYP01CA154778 · NCI · LOYOLA UNIVERSITY CHICAGO · PI NISHIMURA, MICHAEL I. · 2011 to 2015
$15.4M
Investigation of CXCR7 signaling in EGFR TKI resistant NSCLCR01CA230778 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHIMAMURA, TAKESHI · 2019 to 2023
$1.9M
NCI NIH HHS P01 CA154778NCI NIH HHS R01 CA230778
6 · The paper itself

Abstract

Progression on therapy in non-small cell lung carcinoma (NSCLC) is often evaluated radiographically, however, image-based evaluation of said therapies may not distinguish disease progression due to intrinsic tumor drug resistance or inefficient tumor penetration of the drugs. Here we report that the inhibition of mutated

Indexed as

AnimalsAntineoplastic AgentsBiological AvailabilityCarcinoma, Non-Small-Cell LungCell Line, TumorDrug Resistance, NeoplasmEndothelin-1ErbB ReceptorsErlotinib HydrochlorideGefitinibHumansLung NeoplasmsMiceMutationProtein Kinase InhibitorsVascular Endothelial Growth Factor AAntineoplastic AgentsEGFR protein, humanEndothelin-1ErbB ReceptorsErlotinib HydrochlorideGefitinibProtein Kinase InhibitorsVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID32747363
PMCPMC7541638
OpenAlexW3047299983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.