ArticleCarbohydrate polymers2020
Hot melt extrusion paired fused deposition modeling 3D printing to develop hydroxypropyl cellulose based floating tablets of cinnarizine.
Article in Carbohydrate polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Review on 3D Printing Filaments Used in Fused Deposition Modeling Method for Dermatological Preparations.Molecules (Basel, Switzerland) · 2025Review
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- Three-Dimensional Printing Technology in Drug Design and Development: Feasibility, Challenges, and Potential Applications.Journal of personalized medicine · 2024Review
- Mechanical Property of Thermoplastic Polyurethane Vascular Stents Fabricated by Fused Filament Fabrication.Micromachines · 2024Article
- 3D printing processes in precise drug delivery for personalized medicine.Biofabrication · 2024Review
- Article
- Excipients in Pharmaceutical Additive Manufacturing: A Comprehensive Exploration of Polymeric Material Selection for Enhanced 3D Printing.Pharmaceutics · 2024Review
- Effect of Stabilizers and Thermoplastic Polyurethane on the Properties of Three-Dimensional Printed Photochromic Wood Flour/Polylactic Acid Composites.3D printing and additive manufacturing · 2023Article
- Fused Deposition Modelling 3D-Printed Gastro-Retentive Floating Device for Propranolol Hcl Tablets.Polymers · 2023Article
- Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics.Pharmaceutics · 2023Article
- Design and optimization of ciprofloxacin hydrochloride biodegradable 3D printed ocular inserts: Full factorial design and in-vitro and ex-vivo evaluations: Part II.International journal of pharmaceutics · 2023Article
- Polymeric Excipients in the Technology of Floating Drug Delivery Systems.Pharmaceutics · 2022Review
- The Evolution of the 3D-Printed Drug Delivery Systems: A Review.Pharmaceutics · 2022Review
- 3D Printing: Applications in Tissue Engineering, Medical Devices, and Drug Delivery.AAPS PharmSciTech · 2022Review
- Rheological Investigation of Hydroxypropyl Cellulose-Based Filaments for Material Extrusion 3D Printing.Polymers · 2022Article
- Polysaccharide 3D Printing for Drug Delivery Applications.Pharmaceutics · 2022Review
- Three-Dimensional Printing Technologies for Drug Delivery Applications: Processes, Materials, and Effects.International journal of bioprinting · 2022Review
- Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed Caplets: A Quality-by-Design Approach.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Three-dimensional printing could serve as a platform to fabricate individualized medicines and complex-structured solid dosage forms. Herein, hot melt extrusion was coupled with 3D printing to develop a unique gastro retentive dosage form to personalize treatment of cinnarizine or other narrow absorption window drugs. The mechanical strength of the extruded strands was optimized for printing by combining two polymers, hydroxypropyl cellulose and vinylpyrrolidone vinyl acetate copolymer. The unit dose, floating force, and release profile were controlled by the printing parameters and object design. The tablets floated immediately within the FaSSGF, and floating force was relatively constant up to 12 h. Drug release followed zero-order kinetics and could be controlled from 6 h to ≥ 12 h. Input variables had a good correlation (R > 0.95) with unit dose, floating force, and dissolution profile (p < 0.05). Authors successfully proposed and tested a new paradigm of individualized medicine fabrication to meet individual patient needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.