ArticleThe Journal of thoracic and cardiovascular surgery2022
Novel bicuspid aortic valve model with aortic regurgitation for hemodynamic status analysis using an ex vivo simulator.
Article in The Journal of thoracic and cardiovascular surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A Systematic Review of Modeling Platforms for Atrioventricular Valves in Atrioventricular Septal Defects.Journal of cardiovascular translational research · 2026Pooled it
- Design and evaluation of valve interventions using ex vivo biomechanical modeling: the Stanford experience.General thoracic and cardiovascular surgery · 2025Review
- An axis-specific mitral annuloplasty ring eliminates mitral regurgitation allowing mitral annular motion in an ovine model.Communications medicine · 2025Article
- Effect of graft sizing in valve-sparing aortic root replacement for bicuspid aortic valve: The Goldilocks ratio.JTCVS techniques · 2024Article
- Biomechanical engineering analysis of neochordae length's impact on chordal forces in mitral repair.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Article
- Article
- A Comprehensive Review of Management Strategies for Bicuspid Aortic Valve (BAV): Exploring Epidemiology, Aetiology, Aortopathy, and Interventions in Light of Recent Guidelines.Journal of cardiovascular development and disease · 2023Review
- Biomechanics and clinical outcomes of various conduit configurations in valve sparing aortic root replacement.Annals of cardiothoracic surgery · 2023Article
- The Critical Biomechanics of Aortomitral Angle and Systolic Anterior Motion: Engineering Native Ex Vivo Simulation.Annals of biomedical engineering · 2023Article
- Ex vivo biomechanical analysis of the Ross procedure using the modified inclusion technique in a 3-dimensionally printed left heart simulator.The Journal of thoracic and cardiovascular surgery · 2023Article
- Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure.Journal of biomechanical engineering · 2023Article
- Biomechanical evaluation of aortic regurgitation from cusp prolapse using an ex vivo 3D-printed commissure geometric alignment device.Journal of cardiothoracic surgery · 2022Article
- A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis.Nature biomedical engineering · 2022Article
- A Novel Device for Intraoperative Direct Visualization of a Pressurized Root in Aortic Valve Repair.The Annals of thoracic surgery · 2022Article
- Biomechanical engineering analysis of an acute papillary muscle rupture disease model using an innovative 3D-printed left heart simulator.Interactive cardiovascular and thoracic surgery · 2022Article
- Commentary: Valvular mimicry in simulation-espice, adspice, prospice.The Journal of thoracic and cardiovascular surgery · 2022Article
- Biomechanical engineering comparison of four leaflet repair techniques for mitral regurgitation using a novel 3-dimensional-printed left heart simulator.JTCVS techniques · 2021Article
- Videographic conceptual dynamic representation of bicuspid aortic valve anatomic configurations and structural inter-relationships.JTCVS techniques · 2021Article
- Cusp repair techniques in bicuspid and tricuspid aortic valves.JTCVS techniques · 2021Article
- Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities ofFrontiers in cardiovascular medicine · 2021Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objective was to design and evaluate a clinically relevant, novel ex vivo bicuspid aortic valve model that mimics the most common human phenotype with associated aortic regurgitation.
methodsThree bovine aortic valves were mounted asymmetrically in a previously validated 3-dimensional-printed left heart simulator. The non-right commissure and the non-left commissure were both shifted slightly toward the left-right commissure, and the left and right coronary cusps were sewn together. The left-right commissure was then detached and reimplanted 10 mm lower than its native height. Free margin shortening was used for valve repair. Hemodynamic status, high-speed videography, and echocardiography data were collected before and after the repair.
resultsThe bicuspid aortic valve model was successfully produced and repaired. High-speed videography confirmed prolapse of the fused cusp of the baseline bicuspid aortic valve models in diastole. Hemodynamic and pressure data confirmed accurate simulation of diseased conditions with aortic regurgitation and the subsequent repair. Regurgitant fraction postrepair was significantly reduced compared with that at baseline (14.5 ± 4.4% vs 28.6% ± 3.4%; P = .037). There was no change in peak velocity, peak gradient, or mean gradient across the valve pre- versus postrepair: 293.3 ± 18.3 cm/sec versus 325.3 ± 58.2 cm/sec (P = .29), 34.3 ± 4.2 mm Hg versus 43.3 ± 15.4 mm Hg (P = .30), and 11 ± 1 mm Hg versus 9.3 ± 2.5 mm Hg (P = .34), respectively.
conclusionsAn ex vivo bicuspid aortic valve model was designed that recapitulated the most common human phenotype with aortic regurgitation. These valves were successfully repaired, validating its potential for evaluating valve hemodynamics and optimizing surgical repair for bicuspid aortic valves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.