Evidence map›Paper›PMID 32746893›Full record

ArticleArthritis research & therapy2020

Physical activity measured using wearable activity tracking devices associated with gout flares.

Nada Elmagboul, Brian W Coburn, Jeffrey Foster, Amy Mudano, Joshua Melnick, Debra Bergman, Shuo Yang, Lang Chen, Cooper Filby, Ted R Mikuls and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02855437 (Novel Methods for Ascertainment of Gout Flares -A Pilot Study), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02855437 nacompletednot on this map

Novel Methods for Ascertainment of Gout Flares -A Pilot Study

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2016 to 2018Enrolled44ConditionsGoutArmsIVR (Phone call), RheumPro (Smartphone application)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Observational
  5. Article
  6. Article
  7. [Wearables in rheumatology].Zeitschrift fur Rheumatologie · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Use of Consumer Wearable Physical Activity Monitors in Clinical Populations with Functional Limitations.Journal of physical medicine and rehabilitation (Wilmington, Del.) · 2021
    Article
  14. Wearable devices track gout flares.Nature reviews. Rheumatology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nada ElmagboulUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Brian W CoburnUniversity of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Jeffrey FosterUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Amy MudanoUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Joshua MelnickUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Debra BergmanUniversity of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Shuo YangUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Lang ChenUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Cooper FilbyUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Ted R MikulsUniversity of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Jeffrey R CurtisUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.
Kenneth SaagUniversity of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA. ksaag@uabmc.edu.ORCID 0000-0001-6189-8078

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, YING · 2016 to 2025
$42.8M
Training Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6M
NIAMS NIH HHS T32 AR069516NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

objectiveTo determine the feasibility and validity of using wearable activity trackers to test associations between gout flares with physical activity and sleep.

methodsParticipants with physician-diagnosed gout, hyperuricemia (≥ 6.8 mg/dl), current smartphone use, and ≥ 2 self-reported flares in the previous 6 months were enrolled. Physical activity, heart rate, and sleep data were obtained from wearable activity trackers (Fitbit Charge HR2). Daily compliance was defined by the availability of sufficiently complete activity data at least 80% of the day. Associations of weekly gout flares with sleep and activity were measured by comparing flare-related values to average sleep and steps per day. We used mixed linear models to account for repeated observations.

resultsForty-four participants enrolled; 33 met the criteria for minimal wear time and flare reporting, with activity tracker data available for 60.5% of all total study days. Mean ± SD age was 48.8 ± 14.9 years; 85% were men; 15% were black; 88% were on allopurinol or febuxostat, and 30% reported ≥ 6 flares in the prior 6 months. Activity trackers captured 204 (38%) person-weeks with flares and 340 (62%) person-weeks without flares. Mean ± SD daily step count was significantly lower (p < 0.0001) during weeks with gout flares (5900 ± 4071) than during non-flare periods (6972 ± 5214); sleep however did not differ.

conclusionThe pattern of wear in this study illustrates reasonable feasibility of using such devices in future arthritis research. The use of these devices to passively measure changes in physical activity patterns may provide an estimate of gout flare occurrence and duration.

trial registrationNCT, NCT02855437 . Registered 4 August 2016.

Indexed as

GoutWearable Electronic DevicesAdultAllopurinolExerciseFemaleGout SuppressantsHumansMaleMiddle AgedSymptom Flare UpAllopurinolGout SuppressantsGout flaresInteractive voice response systemSmartphone application

Identifiers

PMID32746893
PMCPMC7398057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.