Evidence map›Paper›PMID 32746867›Full record

ArticleMolecular brain2020

Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth.

Zhonggan Ren, Yitong Liu, Wentong Hong, Xinjie Pan, Pifang Gong, Qiong Liu, Guomin Zhou, Song Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhonggan RenDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yitong LiuDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Wentong HongDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Xinjie PanDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Pifang GongDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Qiong LiuDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China;, Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai, 200032, China.
Guomin ZhouDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China;, Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai, 200032, China.
Song QinDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China;, Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai, 200032, China. sqin@fudan.edu.cn.ORCID 0000-0002-5569-4324
Fudan University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptin, secreted by peripheral adipocytes, binds the leptin receptor (Lepr) in the hypothalamus, thereby contributing to the regulation of satiety and body weight. Lepr is expressed in the embryonic brain as early as embryonic day 12.5. However, the function of Lepr in neural precursor cells in the brain has not been resolved. To address this issue, we crossed the Lepr

Indexed as

Cell DifferentiationAnimalsAnimals, NewbornCell LineageHypothalamusIntegrasesLeptinMice, Inbred C57BLMice, KnockoutNestinNeural Stem CellsNeuronsObesityPhenotypePhosphorylationReceptors, LeptinCre recombinaseIntegrasesLeptinNestinReceptors, LeptinSTAT3 Transcription FactorArcuate nucleusHypothalamusLeptin receptorNeural stem cellsNeuronal differentiation

Identifiers

PMID32746867
PMCPMC7398062
OpenAlexW3047204260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.