Evidence map›Paper›PMID 32746846›Full record

ReviewJournal of nanobiotechnology2020

Near-infrared photoresponsive drug delivery nanosystems for cancer photo-chemotherapy.

Xiaoying Wang, Zeliang Xuan, Xiaofeng Zhu, Haitao Sun, Jingchao Li, Zongyu Xie

Open access · goldAbstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 139 citations in OpenAlex.

  1. Review
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  11. CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  19. Smart stimuli-responsive drug delivery systems in spotlight of COVID-19.Asian journal of pharmaceutical sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xiaoying WangXuhui District Center for Disease Control and Prevention, Shanghai, 200237, China.
Zeliang XuanXuhui District Center for Disease Control and Prevention, Shanghai, 200237, China.
Xiaofeng ZhuXuhui District Center for Disease Control and Prevention, Shanghai, 200237, China.
Haitao SunShanghai Institute of Medical Imaging, Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jingchao LiCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China. lijingchao1018@126.com.ORCID http://orcid.org/0000-0002-2651-171X
Zongyu XieDepartment of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, Anhui, China. zongyuxie@sina.com.
Shanghai Municipal Center For Disease Control Prevention · CNDonghua University · CNFirst Affiliated Hospital of Bengbu Medical College · CNSun Yat-sen University · CN

Funding

the Key Project of Natural Science Foundation of Anhui Provincial Department of Education, China KJ2019A0402the Provincial Quality Engineering Key Project of Chinese Institutions of Higher Learning 2019mooc590
6 · The paper itself

Abstract

Drug delivery systems (DDSs) based on nanomaterials have shown a promise for cancer chemotherapy; however, it remains a great challenge to localize on-demand release of anticancer drugs in tumor tissues to improve therapeutic effects and minimize the side effects. In this regard, photoresponsive DDSs that employ light as an external stimulus can offer a precise spatiotemporal control of drug release at desired sites of interest. Most photoresponsive DDSs are only responsive to ultraviolet-visible light that shows phototoxicity and/or shallow tissue penetration depth, and thereby their applications are greatly restricted. To address these issues, near-infrared (NIR) photoresponsive DDSs have been developed. In this review, the development of NIR photoresponsive DDSs in last several years for cancer photo-chemotherapy are summarized. They can achieve on-demand release of drugs into tumors of living animals through photothermal, photodynamic, and photoconversion mechanisms, affording obviously amplified therapeutic effects in synergy with phototherapy. Finally, the existing challenges and further perspectives on the development of NIR photoresponsive DDSs and their clinical translation are discussed.

Indexed as

Antineoplastic AgentsDrug Delivery SystemsPhotochemotherapyAnimalsCell Line, TumorHumansInfrared RaysMiceMice, NudeNeoplasmsAntineoplastic AgentsChemotherapyDrug delivery systemsNanomaterialsNear-infrared lightPhototherapy

Identifiers

PMID32746846
PMCPMC7397640
OpenAlexW3047575674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.