Evidence map›Paper›PMID 32746820›Full record

Trial reportRespiratory research2020

Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort.

Arianne K Baldomero, Chris H Wendt, Ashley Petersen, Nathaniel T Gaeckle, MeiLan K Han, Ken M Kunisaki, COPDGene Investigators

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608764 (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00608764 active not recruitingnot on this map

Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)

TypeobservationalSponsorBrigham and Women's HospitalRan2007 to 2028Enrolled10,718ConditionsPulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arianne K BaldomeroDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Minneapolis VA Health Care System, One Veterans Drive, Mailstop: Pulmonary 111N, Minneapolis, MN, 55417, USA. baldo004@umn.edu.ORCID http://orcid.org/0000-0002-8309-0747
Chris H WendtDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Minneapolis VA Health Care System, One Veterans Drive, Mailstop: Pulmonary 111N, Minneapolis, MN, 55417, USA.
Ashley PetersenDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Nathaniel T GaeckleDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, MN, USA.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Ken M KunisakiDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Minneapolis VA Health Care System, One Veterans Drive, Mailstop: Pulmonary 111N, Minneapolis, MN, 55417, USA.
COPDGene Investigators
University of Minnesota · USUniversity of Michigan · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
NCATS NIH HHS UL1 TR002494NCATS NIH HHS UL1TR002494NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

rationaleGastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency room visits, costs, and quality-of-life impairment. However, it remains unclear whether GERD contributes to the progression of COPD as measured by lung function or computed tomography.

objectiveTo determine the impact of GERD on longitudinal changes in lung function and radiographic lung disease in the COPDGene cohort.

methodsWe evaluated 5728 participants in the COPDGene cohort who completed Phase I (baseline) and Phase II (5-year follow-up) visits. GERD status was based on participant-reported physician diagnoses. We evaluated associations between GERD and annualized changes in lung function [forced expired volume in 1 s (FEV

resultsGERD was reported by 2101 (36.7%) participants at either Phase I and/or Phase II. GERD was not associated with significant differences in slopes of FEV

conclusionsGERD was associated with faster COPD disease progression as measured by rapid FEV CLINICAL TRIALS REGISTRATION: NCT00608764 .

Indexed as

AgedAged, 80 and overCohort StudiesDisease ProgressionFemaleGastroesophageal RefluxHumansLongitudinal StudiesLungMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSpirometryTomography, X-Ray ComputedVital CapacityChronic obstructiveComputed tomographyGastroesophageal refluxLongitudinal studyPulmonary diseaseRespiratory function testsSpirometry

Identifiers

PMID32746820
PMCPMC7397645
OpenAlexW3046725930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.