Evidence map›Paper›PMID 32746800›Full record

ArticleBMC medical imaging2020

Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis.

Ashwag R Alruwaili, Kerstin Pannek, Robert D Henderson, Marcus Gray, Nyoman D Kurniawan, Pamela A McCombe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Personalized Healthcare for Dementia.Healthcare (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ashwag R AlruwailiThe University of Queensland, Centre for Clinical Research, Brisbane, Australia. ashalruwaili@ksu.edu.sa.ORCID 0000-0003-1495-6882
Kerstin PannekAustralian E-Health Research Centre, CSIRO, Brisbane, Australia.
Robert D HendersonSchool of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Marcus GrayCentre for Advanced Imaging, The University of Queensland, Brisbane, Australia.
Nyoman D KurniawanCentre for Advanced Imaging, The University of Queensland, Brisbane, Australia.
Pamela A McCombeThe University of Queensland, Centre for Clinical Research, Brisbane, Australia.
The University of Queensland · AUCommonwealth Scientific and Industrial Research Organisation · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of upper and lower motor neurons. There is a need for an imaging biomarker to track disease progression. Previously, magnetic resonance imaging (MRI) has shown loss of grey and white matter in the brain of patients with ALS compared to controls. We performed serial diffusion tractography imaging (DTI) study of patients with ALS looking for changes over time.

methodsOn all subjects (n = 15), we performed three MRI studies at 6 month intervals. DTI changes were assessed with tract-based spatial statistics (TBSS) and region of interest (ROI) studies. Cortic-spinal tract (CST) was selected for our ROI at the upper level; the posterior limb of internal capsule (PLIC), and a lower level in the pons.

resultsThere was no significant change in DTI measures over 12 months of observation. Better correlation of manual and atlas-based ROI methods was found in the posterior limb of the internal capsule than the pons.

conclusionWhile previous DTI studies showed significant differences between ALS subjects and controls, within individual subjects there is little evidence of progression over 12 months. This suggests that DTI is not a suitable biomarker to assess disease progression in ALS.

Indexed as

AgedAmyotrophic Lateral SclerosisDatabases, FactualDiffusion Tensor ImagingDisease ProgressionFemaleHumansInternal CapsuleMaleMiddle AgedNeuroimagingPonsRadiographic Image Interpretation, Computer-AssistedSensitivity and SpecificityALSAmyotrophic lateral sclerosisDiffusion tensor imagingDTIMNDMotor neuron diseaseRegion of interestROITBSSTract-based spatial statistics

Identifiers

PMID32746800
PMCPMC7397614
OpenAlexW3046669610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.