Evidence map›Paper›PMID 32746765›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2020

Expression of Iron-Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis.

David Hsu, Airie Kim, Tomas Ganz, Jeffrey D Suh, Marilene Wang, Tara J Wu, Jivianne T Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

David HsuDepartment of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Airie KimDivision of Pulmonary Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Tomas GanzDivision of Pulmonary Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Jeffrey D SuhDepartment of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Marilene WangDepartment of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Tara J WuDepartment of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Jivianne T LeeDepartment of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Acute Anemia of Inflammation: Mechanisms and Novel TherapiesK08HL127293 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIM, AIRIE · 2015 to 2019
$824k
NHLBI NIH HHS K08 HL127293
6 · The paper itself

Abstract

Airway epithelia express intrinsic antimicrobial and nutrient-sequestering factors, which contribute to the host defense of the respiratory tract. Hepcidin is an endogenous peptide hormone that serves as a key regulator of iron metabolism, and ferroportin and ZIP8 are iron transporters. All exhibit innate antimicrobial activity. The purpose of this pilot study is to determine if molecules involved in iron regulation are expressed within sinus epithelia and to compare levels of expression between patients with and without chronic rhinosinusitis (CRS). Sinus mucosa was obtained from patients with (n = 19) and without (n = 14) CRS. Real-time polymerase chain reaction following RNA extraction was used to quantify expression of hepcidin, ferroportin, and ZIP8 mRNA. Hepcidin, ferroportin, and ZIP8 were all detected in the sinus epithelia of patients with and without CRS. However, only ZIP8 was significantly changed in CRS, with a 2.5-fold mean increase in mRNA expression relative to controls (

Indexed as

AdultCase-Control StudiesCation Transport ProteinsChronic DiseaseFemaleFerroportinHepcidinsHumansMaleNasal PolypsPilot ProjectsRhinitisSinusitisCation Transport ProteinsFerroportinHepcidinsSLC39A8 protein, humanchronic rhinosinusitisepitheliainnate immunityiron regulationnasal polyposis

Identifiers

PMID32746765
PMCPMC9023122
OpenAlexW3047502272

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.