Evidence map›Paper›PMID 32746643›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Inhibitory activity against carbonic anhydrase IX and XII as a candidate selection criterion in the development of new anticancer agents.

Mikhail Krasavin, Stanislav Kalinin, Tatiana Sharonova, Claudiu T Supuran

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Mikhail KrasavinInstitute of Chemistry, St. Petersburg State University, St. Petersburg, Russia.
Stanislav KalininInstitute of Chemistry, St. Petersburg State University, St. Petersburg, Russia.
Tatiana SharonovaInstitute of Chemistry, St. Petersburg State University, St. Petersburg, Russia.
Claudiu T SupuranNeurofarba Department, Section of Pharmaceutical Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-4262-0323
St Petersburg University · RUUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Analysis of the literature data reveals that while inhibition of cancer-related carbonic anhydrase IX and XII isoforms continues to be an important enrichment factor for designing anticancer agent development libraries, exclusive reliance on the

Indexed as

Drug DevelopmentAntigens, NeoplasmAntineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAntigens, NeoplasmAntineoplastic AgentsCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIIanticancer agentscancer-related IX and XII isoformsCarbonic anhydrase inhibitorsenrichment factorscreening funnel

Identifiers

PMID32746643
PMCPMC7470080
OpenAlexW3047040017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.