Evidence map›Paper›PMID 32746469›Full record

ArticleSeminars in respiratory and critical care medicine2021

Prevention and Management of Delirium in the Intensive Care Unit.

Matthew F Mart, Shawniqua Williams Roberson, Barbara Salas, Pratik P Pandharipande, E Wesley Ely

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 117 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 9 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355053 phase2completednot on this map

Investigation of Sleep in the Intensive Care Unit

TypeinterventionalSponsorMassachusetts General HospitalRan2018 to 2023Enrolled522ConditionsDelirium, SleepArmsDexmedetomidine, Placebo
NCT06029244 nacompletednot on this mapstarted 2024, after this paper: background citation

Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE) : A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2024 to 2025Enrolled160ConditionsDelirium, Delirium in Old Age, Critical Illness, Intensive Care Unit DeliriumArmsEyeControl-Pro, Control
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 9 syntheses or guidelines pooled it, 219 citations in OpenAlex.

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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Matthew F MartDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Shawniqua Williams RobersonCritical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Nashville, Tennessee.
Barbara SalasThe Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Pratik P PandharipandeCritical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Nashville, Tennessee.
E Wesley ElyDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USNewcastle upon Tyne Hospitals NHS Foundation Trust · GB

Funding

Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
NHLBI NIH HHS T32 HL087738
6 · The paper itself

Abstract

Delirium is a debilitating form of brain dysfunction frequently encountered in the intensive care unit (ICU). It is associated with increased morbidity and mortality, longer lengths of stay, higher hospital costs, and cognitive impairment that persists long after hospital discharge. Predisposing factors include smoking, hypertension, cardiac disease, sepsis, and premorbid dementia. Precipitating factors include respiratory failure and shock, metabolic disturbances, prolonged mechanical ventilation, pain, immobility, and sedatives and adverse environmental conditions impairing vision, hearing, and sleep. Historically, antipsychotic medications were the mainstay of delirium treatment in the critically ill. Based on more recent literature, the current Society of Critical Care Medicine (SCCM) guidelines suggest against routine use of antipsychotics for delirium in critically ill adults. Other pharmacologic interventions (e.g., dexmedetomidine) are under investigation and their impact is not yet clear. Nonpharmacologic interventions thus remain the cornerstone of delirium management. This approach is summarized in the ABCDEF bundle (

Indexed as

Critical IllnessDeliriumAdultCritical CareHumansIntensive Care UnitsPain

Identifiers

PMID32746469
PMCPMC7855536
OpenAlexW3047354948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.