ArticleIEEE transactions on biomedical circuits and systems2020
Fully Integrated Time-Gated 3D Fluorescence Imager for Deep Neural Imaging.
Article in IEEE transactions on biomedical circuits and systems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Versatile optical frontends for multicolor fluorescence imaging with miniaturized lensless sensors.Biomedical optics express · 2026Article
- CMOS-EMBEDDED MICROFLUIDICS FOR CHANNEL-ADDRESSABLE PARALLEL READOUT OF SPAD FLUORESCENCE LIFETIME SENSORS.Proceedings. IEEE International Conference on Micro Electro Mechanical Systems · 2026Article
- A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy.IEEE journal of solid-state circuits · 2024Article
- Multicolor fluorescence microscopy for surgical guidance using a chip-scale imager with a low-NA fiber optic plate and a multi-bandpass interference filter.Biomedical optics express · 2024Article
- Towards A Wireless Image Sensor for Real-Time Fluorescence Microscopy in Cancer Therapy.bioRxiv : the preprint server for biology · 2023Article
- Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023Review
- Optics-Free Chip-Scale Intraoperative Imaging Using NIR-Excited Upconverting Nanoparticles.IEEE transactions on biomedical circuits and systems · 2022Article
- Confocal-based fluorescence fluctuation spectroscopy with a SPAD array detector.Light, science & applications · 2021Article
- Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity-at Depth and in Real Time.Neuron · 2020Review
- Fully Integrated Time-Gated 3D Fluorescence Imager for Deep Neural Imaging.IEEE transactions on biomedical circuits and systems · 2020Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
This paper presents a device for time-gated fluorescence imaging in the deep brain, consisting of two on-chip laser diodes and 512 single-photon avalanche diodes (SPADs). The edge-emitting laser diodes deliver fluorescence excitation above the SPAD array, parallel to the imager. In the time domain, laser diode illumination is pulsed and the SPAD is time-gated, allowing a fluorescence excitation rejection up to O.D. 3 at 1 ns of time-gate delay. Each SPAD pixel is masked with Talbot gratings to enable the mapping of 2D array photon counts into a 3D image. The 3D image achieves a resolution of 40, 35, and 73 μm in the x, y, and z directions, respectively, in a noiseless environment, with a maximum frame rate of 50 kilo-frames-per-second. We present measurement results of the spatial and temporal profiles of the dual-pulsed laser diode illumination and of the photon detection characteristics of the SPAD array. Finally, we show the imager's ability to resolve a glass micropipette filled with red fluorescent microspheres. The system's 420 μm-wide cross section allows it to be inserted at arbitrary depths of the brain while achieving a field of view four times larger than fiber endoscopes of equal diameter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.