ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2021
Real-Time Passive Acoustic Mapping Using Sparse Matrix Multiplication.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- A new in silico model to precisely design focused ultrasound brain therapies.Medical physics · 2026Article
- Three-dimensional passive acoustic mapping of high intensity focused ultrasound fields using sparse synthetic apertures from rotated one-dimensional linear arrays.Scientific reports · 2026Article
- Passive Acoustic Dynamic Differentiation and Mapping (PADAM): A Time-Domain Passive Cavitation Localization and Classification Approach.IEEE transactions on bio-medical engineering · 2026Article
- Three-Dimensional Super-Resolution Passive Cavitation Mapping in Laser Lithotripsy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Real-Time Passive Acoustic Mapping With Enhanced Spatial Resolution in Neuronavigation-Guided Focused Ultrasound for Blood-Brain Barrier Opening.IEEE transactions on bio-medical engineering · 2023Article
- Article
- Guiding and monitoring focused ultrasound mediated blood-brain barrier opening in rats using power Doppler imaging and passive acoustic mapping.Scientific reports · 2022Article
- High-spatial-resolution, instantaneous passive cavitation imaging with temporal resolution in histotripsy: a simulation study.Ultrasonography (Seoul, Korea) · 2022Article
- Transcranial Theranostic Ultrasound for Pre-Planning and Blood-Brain Barrier Opening: A Feasibility Study Using an Imaging Phased Array In Vitro and In Vivo.IEEE transactions on bio-medical engineering · 2022Article
- Experimental Demonstration of Trans-Skull Volumetric Passive Acoustic Mapping With the Heterogeneous Angular Spectrum Approach.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound.Advanced drug delivery reviews · 2022Review
- Contrast-Free Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening Using Diffusion Tensor Imaging.IEEE transactions on bio-medical engineering · 2021Article
- Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates.Scientific reports · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Passive acoustic mapping enables the spatiotemporal monitoring of cavitation with circulating microbubbles during focused ultrasound (FUS)-mediated blood-brain barrier opening. However, the computational load for processing large data sets of cavitation maps or more complex algorithms limit the visualization in real-time for treatment monitoring and adjustment. In this study, we implemented a graphical processing unit (GPU)-accelerated sparse matrix-based beamforming and time exposure acoustics in a neuronavigation-guided ultrasound system for real-time spatiotemporal monitoring of cavitation. The system performance was tested in silico through benchmarking, in vitro using nonhuman primate (NHP) and human skull specimens, and demonstrated in vivo in NHPs. We demonstrated the stability of the cavitation map for integration times longer than 62.5 [Formula: see text]. A compromise between real-time displaying and cavitation map quality obtained from beamformed RF data sets with a size of 2000 ×128 ×30 (axial [Formula: see text]) was achieved for an integration time of [Formula: see text], which required a computational time of 0.27 s (frame rate of 3.7 Hz) and could be displayed in real-time between pulses at PRF = 2 Hz. Our benchmarking tests show that the GPU sparse-matrix algorithm processed the RF data set at a computational rate of [Formula: see text]/pixel/sample, which enables adjusting the frame rate and the integration time as needed. The neuronavigation system with real-time implementation of cavitation mapping facilitated the localization of the cavitation activity and helped to identify distortions due to FUS phase aberration. The in vivo test of the method demonstrated the feasibility of GPU-accelerated sparse matrix computing in a close to a clinical condition, where focus distortions exemplify problems during treatment. These experimental conditions show the need for spatiotemporal monitoring of cavitation with real-time capability that enables the operator to correct or halt the sonication in case substantial aberrations are observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.