ReviewCurrent opinion in genetics & development2020
Human adaptation over the past 40,000 years.
Review in Current opinion in genetics & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Natural Selection of the CommonbioRxiv : the preprint server for biology · 2026Article
- "Yet the Problem Remains": Why Genetic Determinism Still Haunts Biomedical Research.Bioethics · 2026Article
- Insights into human adaptation from ancient DNA.Nature genetics · 2026Review
- Article
- Precision nutrition across climates: decoding diet, tradition, and genomic adaptations from South Asia to the Arctic.Frontiers in nutrition · 2025Review
- Selection scan in Native Americans of Mexico identifiesHeliyon · 2024Article
- Adaptive Expression and ncRNA Regulation of Genes Related to Digestion and Metabolism in Stomach of Red Pandas during Suckling and Adult Periods.Animals : an open access journal from MDPI · 2024Article
- Comparative transcriptome and methylome of polar bears, giant and red pandas reveal diet-driven adaptive evolution.Evolutionary applications · 2024Article
- Unveiling recent and ongoing adaptive selection in human populations.PLoS biology · 2024Article
- Human Pangenomics: Promises and Challenges of a Distributed Genomic Reference.Life (Basel, Switzerland) · 2023Review
- The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparative study of the digestion and metabolism related genes' expression changes during the postnatal food change in different dietary mammals.Frontiers in genetics · 2023Article
- The genomic signatures of natural selection in admixed human populations.American journal of human genetics · 2022Article
- Evolution in small steps and giant leaps.Evolution; international journal of organic evolution · 2022Review
- A selection pressure landscape for 870 human polygenic traits.Nature human behaviour · 2021Article
- HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations.EMBO molecular medicine · 2021Article
- Analysis of genetic selection at insulin receptor substrate-2 gene loci.Journal of diabetes and metabolic disorders · 2021Article
- Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years.American journal of human genetics · 2021Article
- The evolution of group differences in changing environments.PLoS biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Over the past few years several methodological and data-driven advances have greatly improved our ability to robustly detect genomic signatures of selection in humans. New methods applied to large samples of present-day genomes provide increased power, while ancient DNA allows precise estimation of timing and tempo. However, despite these advances, we are still limited in our ability to translate these signatures into understanding about which traits were actually under selection, and why. Combining information from different populations and timescales may allow interpretation of selective sweeps. Other modes of selection have proved more difficult to detect. In particular, despite strong evidence of the polygenicity of most human traits, evidence for polygenic selection is weak, and its importance in recent human evolution remains unclear. Balancing selection and archaic introgression seem important for the maintenance of potentially adaptive immune diversity, but perhaps less so for other traits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.