ArticleJournal of affective disorders2020
Suicidal ideation and aggression in childhood, genetic variation and young adult depression.
Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Suicide and Associations with Air Pollution and Ambient Temperature: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Exploring the Association between Aggression and Suicidal Thoughts and Behaviors in an Urban Pediatric Primary Care Setting.Psychiatry international · 2026Article
- Cross-generational transcriptomic effects of alcohol use disorder in third generation offspring.Scientific reports · 2026Article
- Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets.International journal of molecular sciences · 2025Article
- Article
- Reducing Suicidal Ideation in Preadolescents With a History of Foster Care by Promoting School Readiness in Early Childhood.Child maltreatment · 2024Article
- Communication dynamics and media interactions of young adults who have attempted suicide: a qualitative thematic analysis.Frontiers in psychology · 2024Article
- Relationship among Aggression, Non-Suicidal Self-Injury, and Depression in Youths.Iranian journal of public health · 2023Article
- Suicidal Behaviors in Early Adolescence: The Interaction Between School Connectedness and Mental Health.School mental health · 2023Article
- No association of the dopamine D2 receptor genetic bilocus score (rs1800497/rs1799732) on food addiction and food reinforcement in Chilean adults.Frontiers in behavioral neuroscience · 2023Article
- Article
- Advances in Research on Adolescent Suicide and a High Priority Agenda for Future Research.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2021Review
- Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity.Scientific reports · 2021Article
- Aggression and Non-Suicidal Self-Injury among Depressed Youths: The Mediating Effect of Resilience.Iranian journal of public health · 2021Article
- The Co-occurrence of Self-Harm and Aggression: A Cognitive-Emotional Model of Dual-Harm.Frontiers in psychology · 2021Article
- Prevalence and Factors Associated With Suicidal Ideation Among Children and Adolescents Attending a Pediatric HIV Clinic in Uganda.Frontiers in sociology · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSuicidal thoughts and behaviors have been studied in association with a variety of risk factors. The aim of the present study was to determine if levels of child/adolescent aggression and/or variation in candidate genes previously associated with suicidal behaviors in adults would influence the presence of suicidal ideation in childhood/adolescence, and to determine if ideation was associated with young adult depression.
methodsA longitudinal study of children, adolescents and young adults who were at high or low risk for alcohol and other substance use disorders by familial background were assessed. The Child Behavior Checklist (CBCL) aggression scale scores with derived subtypes (physical and relational) and genetic variation (ANKK1, DRD2, COMT, SLC6A4, HTR2C) were used as predictors of the presence and onset of suicidal ideation in childhood using survival analysis. Structural equation models (SEM) were fit to determine the relative importance of the predictors controlling for background variables.
resultsCBCL aggression was significantly associated with child/adolescent suicidal ideation. One SNP in the ANKK1 gene (rs1800497), one in the HTR2C gene (rs6318), and two haplotypes, AAAC in the ANKK1-DRD2 complex and the CCC haplotype of the HTR2C gene, were significantly associated with the presence and onset of child/adolescent suicidal ideation. Follow up in young adulthood showed a significant relationship between suicidal ideation in childhood/adolescence and young adult depression.
conclusionsGenetic variation and presence of elevated aggression scores from the childhood CBCL are significant predictors of childhood suicidal ideation. Suicidal ideation in childhood and being female are predictors of young adult depression.
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