Evidence map›Paper›PMID 32745805›Full record

ArticleJournal of neuroimmunology2020

Bilateral thalamic changes in anti-NMDAR encephalitis presenting with hemichorea and dystonia and acute transient psychotic disorder.

Souvik Dubey, Ritwik Ghosh, Mahua Jana Dubey, Samya Sengupta, Julián Benito-León, Biman Kanti Ray

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of neuroimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. Review
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  9. One Side of the Story; Clues to Etiology in Patients with Asymmetric Chorea.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022
    Review
  10. Article
  11. Anti-Annals of Indian Academy of Neurology
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Souvik DubeyDepartment of Neuromedicine, Bangur Institute of Neurosciences (BIN), Kolkata, West Bengal, India.
Ritwik GhoshDepartment of General Medicine, Burdwan Medical College, Burdwan, West Bengal, India.
Mahua Jana DubeyDepartment of Psychiatry, Berhampore Mental Hospital, Berhampore, West Bengal, India.
Samya SenguptaDepartment of General Medicine, Apollo Gleneagles Hospitals, Kolkata, West Bengal, India.
Julián Benito-LeónDepartment of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Medicine, Universidad Complutense, Madrid, Spain. Electronic address: jbenitol67@gmail.com.
Biman Kanti RayDepartment of Neuromedicine, Bangur Institute of Neurosciences (BIN), Kolkata, West Bengal, India.
Bangur Institute of Neurosciences · INApollo Gleneagles Hospitals · INBerhampur University · INBiomedical Research Networking Center on Neurodegenerative Diseases · ESBurdwan Medical College & Hospital · IN

Funding

ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORR01NS039422 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2000 to 2013
$7.7M
NINDS NIH HHS R01 NS039422
6 · The paper itself

Abstract

Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is one of the most common causes of autoimmune encephalitis. Both movement disorders and neuropsychiatric manifestations are considered core features of anti-NMDAR encephalitis. Strong clinical suspicion, along with NMDAR antibody positivity in paired sample of serum and cerebrospinal fluid, with supportive MRI changes clinch diagnosis in majority. We herein report a case of a middle-aged woman with subacute behavioral abnormalities, which were so severe that forced her to attempt suicide. Hemichorea and dystonia, which appeared later in course, are not previously reported movement disorders in combination in anti-NMDAR encephalitis. Further, magnetic resonance imaging showed bilateral thalamic hyperintensities with diffusion restriction, which are in turn not described in this entity. After amalgamation of history, especially the presence of neuropsychiatric symptoms, clinical features, physical examination, and investigations, the diagnosis of anti-NMDAR encephalitis could be established. Our case not only highlights that the combination of hemichorea and dystonia can be features of anti-NMDAR encephalitis, but adds novelty by bilateral symmetric thalamic changes.

Indexed as

Acute DiseaseAdultAnti-N-Methyl-D-Aspartate Receptor EncephalitisChoreaDystoniaFemaleHumansImmunoglobulins, IntravenousPsychotic DisordersThalamusImmunoglobulins, IntravenousAnti-N-methyl-d-aspartate receptor encephalitisMovement disordersNeuropsychiatric manifestationsThalamus

Identifiers

PMID32745805
PMCPMC7374132
OpenAlexW3045034015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.