ReviewEnvironmental research2020
DNA methylation signature of passive smoke exposure is less pronounced than active smoking: The Understanding Society study.
Review in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course.Molecular psychiatry · 2025Article
- Association of exposure to second-hand smoke during childhood with blood DNA methylation.Environment international · 2025Article
- Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome.Epigenetics · 2024Article
- DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise.Clinical epigenetics · 2024Article
- Comprehensive evaluation of smoking exposures and their interactions on DNA methylation.EBioMedicine · 2024Article
- DNA-Methylation Signatures of Tobacco Smoking in a High Cardiovascular Risk Population: Modulation by the Mediterranean Diet.International journal of environmental research and public health · 2023Article
- Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health.Current environmental health reports · 2022Review
- The potential of DNA methylation as a biomarker for obesity and smoking.Journal of internal medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThe extent of the biological impact of passive smoke exposure is unclear. We sought to investigate the association between passive smoke exposure and DNA methylation, which could serve as a biomarker of health risk. MATERIALS AND
methodsWe derived passive smoke exposure from self-reported questionnaire data among smoking and non-smoking partners of participants enrolled in the UK Household Longitudinal Study 'Understanding Society' (n=769). We performed an epigenome-wide association study (EWAS) of passive smoke exposure with DNA methylation in peripheral blood measured using the Illumina Infinium Methylation EPIC array.
resultsNo CpG sites surpassed the epigenome-wide significance threshold of p<5.97 × 10
conclusionThe DNA methylation signature associated with passive smoke exposure is much less pronounced than that of own smoking, with no positive findings for 'expected' signals. It is unlikely that changes to DNA methylation serve as an important mechanism underlying the health risks of passive smoke exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.